| Enhanced acid protease activity of lysosomes from papillary thyroid carcinoma. | |
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MedLine Citation:
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PMID: 2645038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vitro lysosomal acid protease activity was studied in human papillary thyroid carcinoma (n = 13). As a control, morphologically normal thyroid tissue from the same patient was used in each individual case of carcinoma. Although a marked variation may be observed between individual cases, each examined papillary thyroid carcinoma showed significantly greater activity of acid proteases, both per unit weight of wet thyroid tissue and per unit of lysosomal proteins, in comparison to the corresponding control (range, 24%-248%). In conclusion, it is suggested that enhanced proteolytic activity of lysosomal acid proteases in papillary carcinoma is probably a result of disturbance in catabolic degradation of the thyroglobulin molecule in malignantly transformed thyroid tissue. |
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Authors:
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J Sinadinović; D Cvejić; S Savin; J V Mićić; M Janćić-Zguricas |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Cancer Volume: 63 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-04-05 Completed Date: 1989-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1179-82 Citation Subset: AIM; IM |
Affiliation:
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Institute of Endocrinology, Immunology and Nutrition, Yugoslavia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Papillary
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enzymology* Female Humans Lysosomes / enzymology* Male Peptide Hydrolases / metabolism* Thyroid Neoplasms / enzymology* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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