| Enhanced TLR4 endothelial cell immunohistochemical expression in symptomatic carotid atherosclerotic plaques. | |
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MedLine Citation:
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PMID: 20001205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Toll-like receptor-4 (TLR4) has been linked to the pathogenesis of atherosclerosis. Carotid atheroma endothelial cells (ECs) express TLR4, nevertheless correlations with cerebrovascular symptomatology, epidemiological and clinical variables remain unresolved. METHODS: Carotid atherosclerotic plaques were obtained by standard carotid endarterectomy from 157 patients with carotid artery disease (84 asymptomatic - Group A, 73 symptomatic - Group B). TLR4 expression was detected by immunohistochemistry and TLR4 positivity, overexpression and intensity of immunostaining in ECs were correlated with cerebrovascular symptomatology, epidemiological and clinical variables. RESULTS: A significant association was found between TLR4 positivity in ECs and the occurrence of any cerebrovascular event (overall response (OR): 2.85, 95% CI 1.33 - 6.11, p = 0.009). TLR4 overexpression and staining intensity in ECs were both significantly enhanced in symptomatic patients (p < 0.0001 and p = 0.003, respectively). These associations were stronger for the occurrence of a major cerebrovascular accident (CVA) compared with a transient ischemic attack (TIA) or amaurosis fugax. TLR4 expression in ECs was less prominent in statin users (OR: 0.25, 95%CI 0.1 - 0.58, p = 0.001], while it was enhanced in restenotic plaques compared with primary atherosclerotic lesions (p = 0.012). CONCLUSIONS: TLR4 expression in ECs of carotid atheroma was enhanced in symptomatic patients with most commonly 'unstable' - 'more prone to rupture' carotid plaques. |
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Authors:
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Athanasios Katsargyris; Stamatios E Theocharis; Sotirios Tsiodras; Konstantinos Giaginis; Elias Bastounis; Chris Klonaris |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on therapeutic targets Volume: 14 ISSN: 1744-7631 ISO Abbreviation: Expert Opin. Ther. Targets Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101127833 Medline TA: Expert Opin Ther Targets Country: England |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Affiliation:
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National and Kapodistrian University of Athens, School of Medicine, LAIKON Hospital, Vascular Division, 1st Department of Surgery, Goudi, GR11527, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amaurosis Fugax / metabolism Angiotensin-Converting Enzyme Inhibitors / therapeutic use Anticoagulants / therapeutic use Atherosclerosis / drug therapy, metabolism*, pathology* C-Reactive Protein / metabolism Carotid Arteries / metabolism*, pathology* Carotid Stenosis / metabolism*, pathology* Endarterectomy, Carotid Endothelial Cells / metabolism* Female Graft Occlusion, Vascular / drug therapy, epidemiology Homocysteine / blood Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Immunohistochemistry Ischemic Attack, Transient / metabolism Male Stroke / metabolism Thrombosis / pathology Toll-Like Receptor 4 / biosynthesis*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Anticoagulants; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/TLR4 protein, human; 0/Toll-Like Receptor 4; 454-28-4/Homocysteine; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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