Document Detail


Enhanced Photodynamic Efficacy of Zinc Phthalocyanine by Conjugating to Heptalysine.
MedLine Citation:
PMID:  23057652     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Zinc phthalocyanine (ZnPc) is a promising photosensitizer for photodynamic therapy, but faces some challenges: ZnPc does not dissolve in water and thus require either special formularization of ZnPc, or chemical modification of Pc ring to enhance its bioavailability and photodynamic efficacy. Here, we conjugated mono-substituted ZnPc-COOH with a series of polylysine moiety with different number of lysine residues (ZnPc-(Lys)n (n=1, 3, 5, 7, 9)) to improve the water solubility of ZnPc. We measured the photosensitizing efficacies and the cellular uptakes of this series of conjugates on a normal and a cancerous cell line. Meanwhile, we developed a sensitive in situ method to distinguish the difference of photodynamic efficacy among conjugates. Our results showed that (ZnPc-(Lys)7 has the highest photodynamic efficacy compared to the other conjugates investigated.
Authors:
Mingdong Huang; Zhuo Chen; Linsen Li; Zhipu Luo; Jincan Chen; Shanyong Zhou; Peng Xu; Ping Hu; Jundong Wang; Naisheng Chen; Jinling Huang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Bioconjugate chemistry     Volume:  -     ISSN:  1520-4812     ISO Abbreviation:  Bioconjug. Chem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010319     Medline TA:  Bioconjug Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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