Document Detail

Enhanced L-(+)-lactic acid production by an adapted strain of Rhizopus oryzae using corncob hydrolysate.
MedLine Citation:
PMID:  18415989     Owner:  NLM     Status:  MEDLINE    
Corncob is an economic feedstock and more than 20 million tons of corncobs are produced annually in China. Abundant xylose can be potentially converted from the large amount of hemicellulosic materials in corncobs, which makes the crop residue an attractive alternative substrate for a value-added production of a variety of bioproducts. Lactic acid can be used as a precursor for poly-lactic acid production. Although current industrial lactic acid is produced by lactic acid bacteria using enriched medium, production by Rhizopus oryzae is preferred due to its exclusive formation of the L-isomer and a simple nutrition requirement by the fungus. Production of L-(+)-lactic acid by R. oryzae using xylose has been reported; however, its yield and conversion rate are poor compared with that of using glucose. In this study, we report an adapted R. oryzae strain HZS6 that significantly improved efficiency of substrate utilization and enhanced production of L-(+)-lactic acid from corncob hydrolysate. It increased L-(+)-lactic acid final concentration, yield, and volumetric productivity more than twofold compared with its parental strain. The optimized growth and fermentation conditions for Strain HZS6 were defined.
Dong-Mei Bai; Shi-Zhong Li; Z Lewis Liu; Zhan-Feng Cui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Applied biochemistry and biotechnology     Volume:  144     ISSN:  0273-2289     ISO Abbreviation:  Appl. Biochem. Biotechnol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-04-16     Completed Date:  2008-05-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8208561     Medline TA:  Appl Biochem Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  IM    
Center for Microbial Biotechnology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
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MeSH Terms
Adaptation, Physiological
Animal Feed / analysis
Cellulose / metabolism
Lactic Acid / biosynthesis*,  chemistry
Lignin / metabolism
Rhizopus / metabolism*
Xylose / metabolism
Zea mays / chemistry,  metabolism*
Reg. No./Substance:
0/Xylose; 11132-73-3/lignocellulose; 50-21-5/Lactic Acid; 9004-34-6/Cellulose; 9005-53-2/Lignin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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