Document Detail

Enhanced IL-6 production in aquaporin-4 antibody positive neuromyelitis optica patients.
MedLine Citation:
PMID:  20128675     Owner:  NLM     Status:  MEDLINE    
Anti-aquaporin-4 (Aqp-4) antibody and complement system have emerged as major pathogenic factors in neuromyelitis optica (NMO). To test the significance of interleukin-6 (IL-6), another important humoral immunity factor, in NMO pathogenesis, we measured serum and cerebrospinal fluid (CSF) IL-6 levels of 23 NMO, 11 transverse myelitis, 16 optic neuritis, 27 relapsing remitting multiple sclerosis patients, and 20 neurologically normal controls. NMO and transverse myelitis patients had higher serum and CSF IL-6 levels than other groups. Particularly, anti-Aqp-4 positive NMO patients (n = 12) had higher serum/CSF IL-6 levels than anti-Aqp-4 negative patients (n = 11) and CSF IL-6 levels correlated with anti-Aqp-4 levels and disease severity of the NMO patients. Our results suggest that IL-6 is involved in NMO pathogenesis presumably via anti-Aqp-4 associated mechanisms.
Sema I??z; Erdem T?z?n; Murat K?rt?nc?; Hacer Durmu?; Melike Mutlu; Mefkure Eraksoy; G?l?en Akman-Demir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  120     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Antibodies / blood*,  cerebrospinal fluid
Aquaporin 4 / immunology*
Disability Evaluation
Follow-Up Studies
Immunoprecipitation / methods
Interleukin-6 / blood*,  cerebrospinal fluid*
Linear Models
Multiple Sclerosis / metabolism
Myelitis, Transverse / metabolism
Neuromyelitis Optica / immunology*,  metabolism*
Retrospective Studies
Reg. No./Substance:
0/Antibodies; 0/Aquaporin 4; 0/Interleukin-6

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