| Enhanced excretion of vitamin D binding protein in type 1 diabetes: a role in vitamin D deficiency? | |
| | |
MedLine Citation:
|
PMID: 20943786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONTEXT: Vitamin D deficiency is an increasingly recognized comorbidity in patients with both type 1 (T1D) and type 2 diabetes, particularly associated with the presence of diabetic nephropathy. OBJECTIVE: Because we have previously reported enhanced excretion of megalin in the urine of T1D patients with microalbuminuria, we hypothesized that concurrent urinary loss of the megalin ligand, vitamin D binding protein, might contribute mechanistically to vitamin D deficiency. DESIGN AND PARTICIPANTS: Examining a study cohort of 115 subjects with T1D, aged 14-40 yr, along with 55 age-matched healthy control subjects, we measured plasma and urine concentrations of vitamin D binding protein (VDBP) along with serum concentrations of total calcium, parathyroid hormone, 25-hydroxyvitamin D, and 1, 25-dihydroxyvitamin D; these results were compared between groups and investigated for relationships with metabolic control status or with albuminuria. MAIN OUTCOME MEASURE: Between-group differences in urinary VDBP concentration were the main outcome measures. RESULTS: A marked increase in the urinary excretion of VDBP was apparent in subjects with T1D, compared with control subjects. Using multivariate regression modeling, significant correlates of urinary VDBP excretion included microalbuminuria (P = 0.004), glycosylated hemoglobin (P = 0.010), continuous glucose monitoring system average capillary glucose (P = 0.047), and serum 1,25(OH)(2)D concentrations (P = 0.037). Vitamin D deficiency or insufficiency was slightly more prevalent in diabetic subjects with albuminuria, coincident with the increase in urine VDBP excretion. CONCLUSIONS: These findings suggest that, theoretically, exaggerated urinary loss of VDBP in T1D, particularly in persons with albuminuria, could contribute mechanistically to vitamin D deficiency in this disease. |
| | |
Authors:
|
Kathryn M Thrailkill; Chan-Hee Jo; Gael E Cockrell; Cynthia S Moreau; John L Fowlkes |
Related Documents
:
|
16486726 - Mutual passivation of donors and isovalent nitrogen in gaas. 1098356 - Effect of cobalt salts on the glycemia and islet histology of channa punctatus (bloch). 11897186 - Ontogeny of thermoregulation in precocial birds. 11895466 - Helicobacter pylori masks differences in homocysteine plasma levels between controls an... 43016 - Stereological study of b-cell mitochondria in alloxan-treated mice. 1801056 - Patterns of insulin dependence in an african diabetic clinic. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-13 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: 96 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-06 Completed Date: 2011-02-04 Revised Date: 2012-01-02 |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 142-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA. thrailkillkathrynm@uams.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Blood Glucose / metabolism Calcium / blood Diabetes Mellitus, Type 1 / complications, metabolism* Female Humans Male Parathyroid Hormone / blood Regression Analysis Vitamin D / analogs & derivatives, blood Vitamin D Deficiency / complications, metabolism* Vitamin D-Binding Protein / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
C06RR16517/RR/NCRR NIH HHS; M01 RR14288/RR/NCRR NIH HHS; R01-DK62999/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Parathyroid Hormone; 0/Vitamin D-Binding Protein; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; 66772-14-3/1,25-dihydroxyvitamin D; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, ...
Next Document: Elevated corticotropin releasing hormone (CRH) during pregnancy and risk of postpartum depression (P...