Document Detail

Enhanced cardiovascular protective effects of valsartan in high-risk hypertensive patients with left ventricular hypertrophy--sub-analysis of the KYOTO HEART study.
MedLine Citation:
PMID:  21436597     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objective of the present study was to examine whether baseline electrocardiographically diagnosed left ventricular hypertrophy (ECG-LVH) influenced the angiotensin II receptor blocker (ARB) valsartan add-on effects on the cardio-cerebrovascular morbidity and mortality in the high-risk hypertensive patients who participated in the KYOTO HEART Study.
METHODS AND RESULTS: The primary endpoint was the same as in the main study: a composite of defined cardiovascular and cerebrovascular events. The median follow-up period was 3.27 years. The study group was divided into 2 groups according to the presence of ECG-LVH: with LVH, n=803; without LVH, n=2,228. The primary endpoint events occurred more frequently in patients with LVH than in patients without LVH (9.3% vs. 7.3%; hazard ratio [HR], 1.33; 95% confidence interval [CI]: 1.01-1.75). Valsartan add-on significantly decreased the occurrence of primary endpoint events in both LVH-positive patients (5.8% vs. 12.9%; HR, 0.45; 95%CI: 0.28-0.72) and LVH-negative patients (5.5% vs. 9.2%; HR, 0.59; 95%CI: 0.44-0.81) compared with non-ARB treatment. The reduction in combined cardiovascular events (composite of acute myocardial infarction, angina pectoris, and heart failure) due to valsartan treatment in patients with LVH was significantly larger than that in patients without LVH (P<0.0001). Changes in blood pressure during the follow-up period did not differ significantly among the study subgroups.
CONCLUSIONS: High-risk hypertensive patients with ECG-LVH might gain more cardiovascular benefits from valsartan add-on treatment, compared with patients without ECG-LVH.
Jun Shiraishi; Takahisa Sawada; Shinzo Kimura; Hiroyuki Yamada; Hiroaki Matsubara;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Retracted Publication     Date:  2011-03-19
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-28     Completed Date:  2011-08-12     Revised Date:  2013-03-28    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  806-14     Citation Subset:  IM    
Copyright Information:
All rights are reserved to the Japanese Circulation Society.
Department of Cardiology, Kyoto First Red Cross Hospital, Kyoto 605-0981, Japan.
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / administration & dosage*,  adverse effects
Follow-Up Studies
Hypertension / diagnosis,  drug therapy*,  mortality
Hypertrophy, Left Ventricular / diagnosis,  drug therapy*,  mortality
Middle Aged
Risk Factors
Tetrazoles / administration & dosage*,  adverse effects
Valine / administration & dosage,  adverse effects,  analogs & derivatives*
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Tetrazoles; 137862-53-4/valsartan; 7004-03-7/Valine
Retraction In:
Shimokawa H. Circ J. 2013;77(2):552b   [PMID:  23358392 ]

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