Document Detail


Enhanced 2,3-butanediol production by altering the mixed acid fermentation pathway in Klebsiella oxytoca.
MedLine Citation:
PMID:  18008166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Klebsiella oxytoca mutants were isolated from the wild type strain ME-303 after mutagenesis with UV coupled with diethyl sulfate and the following modified proton suicide method. By analyzing the activities of lactate dehydrogenase and phosphotransacetylase involved in lactic and acetic acid formation pathways and batch fermentation, one mutant, ME-UD-3, was isolated that produced 7.8% more 2,3-butanediol than ME-303 with the corresponding byproducts of lactic and acetic acid decreased by 88% and 92%, respectively.
Authors:
Xiao-Jun Ji; He Huang; Shuang Li; Jun Du; Min Lian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-15
Journal Detail:
Title:  Biotechnology letters     Volume:  30     ISSN:  0141-5492     ISO Abbreviation:  Biotechnol. Lett.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008051     Medline TA:  Biotechnol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  731-4     Citation Subset:  IM    
Affiliation:
College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing 210009, P.R. China.
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MeSH Terms
Descriptor/Qualifier:
Acetic Acid / metabolism
Butylene Glycols / metabolism*
Fermentation*
Klebsiella oxytoca / genetics,  growth & development,  metabolism*
Lactic Acid / metabolism
Mutagenesis
Chemical
Reg. No./Substance:
0/Butylene Glycols; 50-21-5/Lactic Acid; 513-85-9/2,3-butylene glycol; 64-19-7/Acetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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