| Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. | |
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MedLine Citation:
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PMID: 11449279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genetic studies have identified over a dozen genes that function in programmed cell death (apoptosis) in the nematode Caenorhabditis elegans. Although the ultimate effects on cell survival or engulfment of mutations in each cell death gene have been extensively described, much less is known about how these mutations affect the kinetics of death and engulfment, or the interactions between these two processes. We have used four-dimensional-Nomarski time-lapse video microscopy to follow in detail how cell death genes regulate the extent and kinetics of apoptotic cell death and removal in the early C. elegans embryo. Here we show that blocking engulfment enhances cell survival when cells are subjected to weak pro-apoptotic signals. Thus, genes that mediate corpse removal can also function to actively kill cells. |
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Authors:
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D J Hoeppner; M O Hengartner; R Schnabel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nature Volume: 412 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-12 Completed Date: 2001-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 202-6 Citation Subset: IM |
Affiliation:
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Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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genetics,
physiology Animals Apoptosis* / genetics Caenorhabditis elegans / cytology, embryology, genetics* Caenorhabditis elegans Proteins* Caspases / genetics*, physiology Cell Lineage Genes, Helminth Helminth Proteins / genetics*, physiology Microscopy, Video Mutation Phagocytosis / genetics* Phosphoproteins / genetics, physiology Video Recording |
| Chemical | |
Reg. No./Substance:
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0/ATP-Binding Cassette Transporters; 0/CED-6 protein, C elegans; 0/CED-7 protein, C elegans; 0/Caenorhabditis elegans Proteins; 0/Helminth Proteins; 0/Phosphoproteins; EC 3.4.22.-/Caspases; EC 3.4.22.-/ced-3 protein, C elegans |
| Comments/Corrections | |
Comment In:
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Nature. 2001 Jul 12;412(6843):133-5
[PMID:
11449252
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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