Document Detail


Engineering of secondary metabolite pathways.
MedLine Citation:
PMID:  14662388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nature produces an astonishing wealth of secondary metabolites with important biological functions. To access this diversity of structurally complex chemical compounds for industrial and biomedical applications, cells have been engineered to produce higher levels and/or novel compounds that were previously inaccessible. Recent examples of metabolic and combinatorial engineering illustrate different strategies for the production of secondary metabolites in microbial cells.
Authors:
Benjamin N Mijts; Claudia Schmidt-Dannert
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  14     ISSN:  0958-1669     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-09     Completed Date:  2004-08-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  597-602     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, 140 Gortner Laboratory, Saint Paul, MN 55108, USA.
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MeSH Terms
Descriptor/Qualifier:
Biopolymers / biosynthesis,  chemistry
Carotenoids / biosynthesis,  chemistry
Escherichia coli / genetics,  metabolism
Genetic Engineering*
Models, Biological
Multienzyme Complexes / biosynthesis
Yeasts / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Biopolymers; 0/Multienzyme Complexes; 36-88-4/Carotenoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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