| Engineering a new mouse model for vitiligo. | |
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MedLine Citation:
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PMID: 22695284 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Although the precise mechanisms that trigger vitiligo remain elusive, autoimmune responses mediate its progression. The development of therapies has been impeded by a paucity of animal models, since mice lack interfollicular melanocytes, the primary targets in vitiligo. In this issue, Harris et al. describe a mouse model in which interfollicular melanocytes are retained by Kit ligand overexpression and an immune response is initiated by transplanting melanocyte-targeting CD8+ T cells. |
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Authors:
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Prashiela Manga; Seth J Orlow |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 132 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 1752-5 Citation Subset: IM |
Affiliation:
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The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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