Document Detail


Engineering multicellular traits in synthetic microbial populations.
MedLine Citation:
PMID:  22591687     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Without cell-to-cell communication, the organization and regulation of specialized cell types that underpin the development and physiology of multicellular organisms would be impossible. In nature, unicellular microbes have also been shown to display multicellular-like traits, such as intercellular communication, division of labor, and cooperative coordination of cellular activities. Likewise, the incorporation of artificial cell-to-cell communication into genetic circuit designs is enabling synthetic biologists to move from programming single cells towards the engineering of population-level behaviors and functions, such as diversification, spatial organization, synchronization, and coordinated information processing. The disciplined engineering goal of routinely building complex genetic circuits from well-characterized modules still poses challenges, owing to reusability and input-output matching problems resulting from information transfer being mediated through diffusible molecules. Optogenetic interfaces between circuits are considered as a possible solution.
Authors:
John S Chuang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-14
Journal Detail:
Title:  Current opinion in chemical biology     Volume:  -     ISSN:  1879-0402     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9811312     Medline TA:  Curr Opin Chem Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratory of Living Matter, and Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
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