Document Detail


Engineering multicellular systems by cell-cell communication.
MedLine Citation:
PMID:  19733047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Synthetic biology encompasses the design of new biological parts and systems as well as the modulation of existing biological networks to generate novel functions. In recent years, increasing emphasis has been placed on the engineering of population-level behaviors using cell-cell communication. From the engineering perspective, cell-cell communication serves as a versatile regulatory module that enables coordination among cells in and between populations and facilitates the generation of reliable dynamics. In addition to exploring biological 'design principles' via the construction of increasingly complex dynamics, communication-based synthetic systems can be used as well-defined model systems to study ecological and social interactions such as competition, cooperation, and predation. Here we discuss the dynamic properties of cell-cell communication modules, how they can be engineered for synthetic circuit design, and applications of these systems.
Authors:
Anand Pai; Yu Tanouchi; Cynthia H Collins; Lingchong You
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2009-09-03
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  20     ISSN:  1879-0429     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-01-21     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  461-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Communication*
Genes, Bacterial
Models, Theoretical
Grant Support
ID/Acronym/Agency:
P50 GM081883/GM/NIGMS NIH HHS; P50 GM081883-020002/GM/NIGMS NIH HHS; R01 CA118486/CA/NCI NIH HHS; R01 CA118486-03/CA/NCI NIH HHS
Comments/Corrections

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