Document Detail


Engineering hydrogels as extracellular matrix mimics.
MedLine Citation:
PMID:  20394538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extracellular matrix (ECM) is a complex cellular environment consisting of proteins, proteoglycans, and other soluble molecules. ECM provides structural support to mammalian cells and a regulatory milieu with a variety of important cell functions, including assembling cells into various tissues and organs, regulating growth and cell-cell communication. Developing a tailored in vitro cell culture environment that mimics the intricate and organized nanoscale meshwork of native ECM is desirable. Recent studies have shown the potential of hydrogels to mimic native ECM. Such an engineered native-like ECM is more likely to provide cells with rational cues for diagnostic and therapeutic studies. The research for novel biomaterials has led to an extension of the scope and techniques used to fabricate biomimetic hydrogel scaffolds for tissue engineering and regenerative medicine applications. In this article, we detail the progress of the current state-of-the-art engineering methods to create cell-encapsulating hydrogel tissue constructs as well as their applications in in vitro models in biomedicine.
Authors:
Hikmet Geckil; Feng Xu; Xiaohui Zhang; SangJun Moon; Utkan Demirci
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nanomedicine (London, England)     Volume:  5     ISSN:  1748-6963     ISO Abbreviation:  Nanomedicine (Lond)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-07-05     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101278111     Medline TA:  Nanomedicine (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomimetic Materials / chemistry*
Extracellular Matrix / chemistry*
Humans
Hydrogels / chemistry*
Tissue Engineering / methods*,  trends
Grant Support
ID/Acronym/Agency:
R01 AI081534/AI/NIAID NIH HHS; R01 AI081534-02/AI/NIAID NIH HHS; R21 AI087107/AI/NIAID NIH HHS; R21 AI087107-02/AI/NIAID NIH HHS; R21 EB007707/EB/NIBIB NIH HHS; R21 EB007707-02/EB/NIBIB NIH HHS; R21-EB007707/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Hydrogels
Comments/Corrections

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