| Engineering blood vessels by gene and cell therapy. | |
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MedLine Citation:
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PMID: 17696817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular-related syndromes are the leading cause of morbidity and mortality worldwide. Arterial narrowing and blockage due to atherosclerosis cause reduced blood flow to the brain, heart and legs. Bypass surgery to improve blood flow to the heart and legs in these patients is performed in hundreds of thousands of patients every year. Autologous grafts, such as the internal thoracic artery and saphenous vein, are used in most patients, but in a significant number of patients such grafts are not available and synthetic grafts are used. Synthetic grafts have higher failure rates than autologous grafts due to thrombosis and scar formation within graft lumen. Cell and gene therapy combined with tissue engineering hold a great promise to provide grafts that will be biocompatible and durable. This review describes the field of vascular grafts in the context of tissue engineering using cell and gene therapies. |
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Authors:
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Gabriel Zarbiv; Meir Preis; Yaara Ben-Yosef; Moshe Y Flugelman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: 7 ISSN: 1744-7682 ISO Abbreviation: Expert Opin Biol Ther Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: England |
Other Details:
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Languages: eng Pagination: 1183-91 Citation Subset: IM |
Affiliation:
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MultiGene Vascular Systems Ltd, Lady Davis Carmel Medical Center, Haifa, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessel Prosthesis / trends Blood Vessels / cytology*, transplantation* Cell Transplantation / methods*, trends Gene Therapy / methods*, trends Humans Tissue Engineering / methods*, trends |
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