Document Detail


Engineering analysis of penile hemodynamic and structural-dynamic relationships: Part I--Clinical implications of penile tissue mechanical properties.
MedLine Citation:
PMID:  9542686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The least investigated physical determinant of penile rigidity has been penile tissue material properties. The goals in this study (Part I) were to define two penile mechanical parameters, cavernosal expandability X and tunical distensibility VE/VF, determine their magnitudes in humans and develop an analytical expression for penile volume as a function of these two tissue characteristics and intracavernosal pressure. METHODS: Dynamic infusion pharmacocavernosometry was performed in 21 impotent patients (age 43 +/- 19 y) to provide human geometric, hemodynamic and structural data. A mathematically derived model of hemodynamic and structural-dynamic characteristics of penile erection was developed (Parts I, II, III) incorporating penile tissue mechanical qualities. RESULTS: Cavernosal expandability X provided a measure of the ability to approach maximum volume at relatively low intracavernosal pressures. Tunical distensibility VE/VF denoted the maximal erect to flaccid penile volume ratio. The magnitudes of X and VE/VF in the study population were 0.04-0.17 mmHg-1 and 1.7-5.0 respectively. CONCLUSIONS: Enabling penile volume to be derived as a function of tissue mechanical characteristics and pressure, allows for penile rigidity to be expressed (in Part II) as a function of pressure, geometry and tissue qualities.
Authors:
D Udelson; A Nehra; D G Hatzichristou; K Azadzoi; R B Moreland; J Krane; I S Saenz de Tejada; I Goldstein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of impotence research     Volume:  10     ISSN:  0955-9930     ISO Abbreviation:  Int. J. Impot. Res.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-26     Completed Date:  1998-05-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007383     Medline TA:  Int J Impot Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  15-24     Citation Subset:  IM    
Affiliation:
Department of Urology, Boston University School of Medicine, MA 02118, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biomechanics
Compliance
Erectile Dysfunction / physiopathology*
Hemodynamics
Humans
Male
Mathematics
Middle Aged
Models, Biological
Penile Erection*
Penis / blood supply*,  pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
DK-39080/DK/NIDDK NIH HHS; DK-40025/DK/NIDDK NIH HHS; DK-40487/DK/NIDDK NIH HHS
Comments/Corrections
Comment In:
Int J Impot Res. 2000 Feb;12(1):3-8   [PMID:  10982306 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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