Document Detail


Engineering 3D Bio-artificial Heart Muscle: The Acellular Ventricular Extracellular Matrix Model.
MedLine Citation:
PMID:  25248038     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Current therapies in left ventricular systolic dysfunction and end stage heart failure include mechanical assist devices and/or transplant. The development of a tissue-engineered integrative platform would present a therapeutic option which overcomes the limitations associated with current treatment modalities. This study provides a foundation for the fabrication and preliminary viability of the Acellular Ventricular Extracellular Matrix (AVEM) model. AVEM were fabricated by culturing 4 million rat neonatal cardiac cells around an excised acellular ventricular segment. AVEM generated a maximum spontaneous contractile force of 388.3µN and demonstrated a Frank-Starling relationship at varying pretensions. Histological assessment displayed cell cohesion and adhesion within the AVEM as a result of passive cell seeding.
Authors:
Nikita M Patel; Ze-Wei Tao; Mohamed A Mohamed; Matt K Hogan; Laura Gutierrez; Ravi K Birla
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-22
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  -     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-23     Completed Date:  -     Revised Date:  2014-9-24    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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