Document Detail

Engineering 3D Bio-artificial Heart Muscle: The Acellular Ventricular Extracellular Matrix Model.
MedLine Citation:
PMID:  25248038     Owner:  NLM     Status:  Publisher    
Current therapies in left ventricular systolic dysfunction and end stage heart failure include mechanical assist devices and/or transplant. The development of a tissue-engineered integrative platform would present a therapeutic option which overcomes the limitations associated with current treatment modalities. This study provides a foundation for the fabrication and preliminary viability of the Acellular Ventricular Extracellular Matrix (AVEM) model. AVEM were fabricated by culturing 4 million rat neonatal cardiac cells around an excised acellular ventricular segment. AVEM generated a maximum spontaneous contractile force of 388.3µN and demonstrated a Frank-Starling relationship at varying pretensions. Histological assessment displayed cell cohesion and adhesion within the AVEM as a result of passive cell seeding.
Nikita M Patel; Ze-Wei Tao; Mohamed A Mohamed; Matt K Hogan; Laura Gutierrez; Ravi K Birla
Related Documents :
25225208 - Biophysical characterization of the underappreciated and important relationship between...
25447348 - Cardiac rehabilitation improves functional capacity and patient-reported health status ...
511298 - Permeability factor contaminating hyaluronidase preparations.
3831028 - Migration and torsions of the conotruncus in the chick embryo heart: observational evid...
25439048 - Impact of diabetes-related complications on healthcare costs: new results from the uk p...
24252288 - Qtc compared to the jtc for monitoring of drug-induced repolarization, changes in the s...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-22
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  -     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-23     Completed Date:  -     Revised Date:  2014-9-24    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of a Value-Based Insurance Design for Back Pain on Health Plan Member Satisfaction and Its Im...
Next Document:  Particle Embolization for the Treatment of Life-Threatening Epistaxis in a Left Ventricular Assist D...