| Engineered embryonic endothelial progenitor cells as therapeutic Trojan horses. | |
| | |
MedLine Citation:
|
PMID: 15144946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
While the hematogenic contribution of circulating endothelial cells to tumor angiogenesis is not entirely understood, one can exploit this phenomenon as a therapeutic strategy. In this issue of Cancer Cell, show that murine embryonic endothelial progenitor cells preferentially home to sites of lung metastases, evade immunological rejection, and can exert a bystander antitumor effect when modified to contain a suicide gene construct that activates a prodrug. Treatment with the prodrug led to improved survival in syngeneic and nonsyngeneic tumor-bearing mouse models. The conceptual advance put forward by this study might result in translational applications. |
| | |
Authors:
|
Wadih Arap; Renata Pasqualini |
Related Documents
:
|
18243696 - A cell-penetrating peptidic grp78 ligand for tumor cell-specific prodrug therapy. 19565926 - Tumor-targeted salmonella typhimurium overexpressing cytosine deaminase: a novel, tumor... 7889476 - Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus ... 22729036 - High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma ... 7549756 - High prevalence of expression of p53 oncoprotein in oral carcinomas from india associat... 17482226 - (anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, mcf-7 ... |
Publication Detail:
|
Type: Comment; Editorial |
Journal Detail:
|
Title: Cancer cell Volume: 5 ISSN: 1535-6108 ISO Abbreviation: Cancer Cell Publication Date: 2004 May |
Date Detail:
|
Created Date: 2004-05-17 Completed Date: 2004-06-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101130617 Medline TA: Cancer Cell Country: United States |
Other Details:
|
Languages: eng Pagination: 406-8 Citation Subset: IM |
Affiliation:
|
The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anoxia Endothelium, Vascular / embryology* Gene Targeting Gene Therapy* Genes, Transgenic, Suicide* Genetic Engineering Lung Neoplasms / secondary, therapy* Mice Neovascularization, Pathologic / prevention & control Prodrugs / metabolism Stem Cells / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Prodrugs |
| Comments/Corrections | |
Comment On:
|
Cancer Cell. 2004 May;5(5):477-88
[PMID:
15144955
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intratumoral hypoxia, radiation resistance, and HIF-1.
Next Document: Cysteine cathepsins (proteases)--on the main stage of cancer?