Document Detail

Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms.
MedLine Citation:
PMID:  17946863     Owner:  NLM     Status:  MEDLINE    
For efficiently assessing the potential for grafted cells to repair infarcted myocardium, a simplified surrogate heart muscle system would offer numerous advantages. Using neonatal rat cardiac myocytes in a collagen matrix, we created thin cylindrical engineered cardiac tissues (ECTs) that exhibit essential aspects of physiologic cardiac muscle function. Furthermore, a novel cryo-injured ECT model of myocardial infarction offers the potential for the longitudinal study of mechanisms of cell-based cardiac repair in vitro.
Do Eun Kim; Eun Jung Lee; Timothy P Martens; Rina Kara; Hina W Chaudhry; Silviu Itescu; Kevin D Costa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  1     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2006  
Date Detail:
Created Date:  2007-10-23     Completed Date:  2008-03-19     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  849-52     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Cell Culture Techniques / methods
Cells, Cultured
Heart / physiology*
Myocardial Contraction / physiology*
Myocytes, Cardiac / cytology,  physiology*
Rats, Sprague-Dawley
Regeneration / physiology*
Tissue Engineering / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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