| Engineered biological nanofactories trigger quorum sensing response in targeted bacteria. | |
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MedLine Citation:
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PMID: 20081846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biological nanofactories, which are engineered to contain modules that can target, sense and synthesize molecules, can trigger communication between different bacterial populations. These communications influence biofilm formation, virulence, bioluminescence and many other bacterial functions in a process called quorum sensing. Here, we show the assembly of a nanofactory that can trigger a bacterial quorum sensing response in the absence of native quorum molecules. The nanofactory comprises an antibody (for targeting) and a fusion protein that produces quorum molecules when bound to the targeted bacterium. Our nanofactory selectively targets the appropriate bacteria and triggers a quorum sensing response when added to two populations of bacteria. The nanofactories also trigger communication between two bacterial populations that are otherwise non-communicating. We envision the use of these nanofactories in generating new antimicrobial treatments that target the communication networks of bacteria rather than their viability. |
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Authors:
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Rohan Fernandes; Varnika Roy; Hsuan-Chen Wu; William E Bentley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-01-17 |
Journal Detail:
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Title: Nature nanotechnology Volume: 5 ISSN: 1748-3395 ISO Abbreviation: Nat Nanotechnol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-06-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101283273 Medline TA: Nat Nanotechnol Country: England |
Other Details:
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Languages: eng Pagination: 213-7 Citation Subset: IM |
Affiliation:
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Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Bacterial
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metabolism,
pharmacology* Drug Delivery Systems / methods Escherichia coli / metabolism Flow Cytometry Homoserine / analogs & derivatives*, metabolism, pharmacology Immunoglobulin G / metabolism, pharmacology Lactones / metabolism, pharmacology* Nanostructures / chemistry* Nanotechnology / methods* Quorum Sensing / drug effects* Recombinant Fusion Proteins / metabolism, pharmacology Salmonella / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Immunoglobulin G; 0/Lactones; 0/N-octanoylhomoserine lactone; 0/Recombinant Fusion Proteins; 498-19-1/Homoserine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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