| Engineered Andrographolide Nanoparticles Mitigate Paracetamol Hepatotoxicity in Mice. | |
| | |
MedLine Citation:
|
PMID: 23319171 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: Paracetamol (acetaminophen, APAP) overdose is often fatal due to progressive and irreversible hepatic necrosis. The aim of this work was to design Andrographolide (AG) loaded nanoparticles to prevent similar hepatic necrosis. METHODS: Functionalized AG-loaded PLGA nanoparticles carrying different densities of heparin were prepared following a facile emulsion solvent evaporation technique. Nanoparticle morphology, loading and release kinetics were studied. Hepatic localization of the nanoparticles was investigated in both normal and APAP damaged conditions using FITC fluorescent probe. Different serum parameters and liver histopathology were further examined as indicators of hepatic condition before and after treatment. RESULT: A collection of heparin functionalized AG-loaded PLGA nanoparticles were designed. Low amount of heparin on the particle surface could rapidly localize the nanoparticles up to the liver. The new functionalized AG nanoparticles affect efficient hepatoprotection in experimental mouse APAP overdose conditions. AG nanoparticle hepatoprotection was due to the rapid regeneration of antioxidant capacity and hepatic GSH store. CONCLUSIONS: Engineered nanoparticles loaded with AG provided a fast protection in APAP induced acute liver failure. |
| | |
Authors:
|
Partha Roy; Suvadra Das; Runa Ghosh Auddy; Achintya Saha; Arup Mukherjee |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-15 |
Journal Detail:
|
Title: Pharmaceutical research Volume: - ISSN: 1573-904X ISO Abbreviation: Pharm. Res. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8406521 Medline TA: Pharm Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Pharmaceutical and Fine Chemicals Technology Department of Chemical Technology, University of Calcutta, 92, APC Road, Kolkata, 700009, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Design and Characterization of a Novel Fluorinated Magnetic Resonance Imaging Agent for Functional A...
Next Document: Effects of Ionic Strength and Sugars on the Aggregation Propensity of Monoclonal Antibodies: Influen...