Document Detail


Enfurvitide prevents vertical transmission of multidrug-resistant HIV-1 in pregnancy but does not cross the placenta.
MedLine Citation:
PMID:  16511429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of previously successful antiretroviral regimens in mother-to-child transmission (MTCT) prevention will be increasingly challenged by the rising prevalence of multidrug-resistant (MDR) HIV. We used enfurvitide together with an optimized antiretroviral backbone to prevent the MTCT prevention of MDR HIV in two pregnant women. The measurement of maternal and foetal peripheral blood levels of enfurvitide showed no evidence of transplacental transfer.
Authors:
Paul Brennan-Benson; Mark Pakianathan; Philip Rice; Stefano Bonora; Rana Chakraborty; Michael Sharland; Phillip Hay
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  AIDS (London, England)     Volume:  20     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-03-02     Completed Date:  2006-12-07     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  297-9     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adult
Drug Resistance, Multiple, Viral
Female
HIV Envelope Protein gp41 / therapeutic use*
HIV Fusion Inhibitors / pharmacokinetics,  therapeutic use
HIV Infections / drug therapy*,  transmission
HIV-1 / drug effects*
Humans
Infectious Disease Transmission, Vertical / prevention & control*
Maternal-Fetal Exchange
Peptide Fragments / pharmacokinetics,  therapeutic use*
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Chemical
Reg. No./Substance:
0/HIV Envelope Protein gp41; 0/HIV Fusion Inhibitors; 0/Peptide Fragments; 19OWO1T3ZE/enfuvirtide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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