Document Detail

Enforcement of specific unresponsiveness by the long-term presence of allogeneic heart grafts.
MedLine Citation:
PMID:  6229915     Owner:  NLM     Status:  MEDLINE    
Mechanisms underlying the maintenance of long-term heart allografts were analyzed in rats treated with Cyclosporine. It was shown that acceptance of allografts after cyclosporine did not involve the attenuation of immunogenicity of the grafts. This conclusion was drawn from two observations: (1) Pretreatment of the donors with cyclosporine did not cause prolongation of graft survival time; and (2) cyclosporine stabilized allografts were normally rejected by secondary recipients when retransplanted on day 30. Studies of the acceptance of skin grafts from the heart donor strain indicated the existence of a mechanism to maintain donor-specific unresponsiveness in the presence of a stable allograft in a time-dependent manner. Thus, the mean rejection time of F344 skin grafts on WKA rats bearing F344 hearts was more than 80 days when transplanted on day 210, but it was 32 days when they were transplanted on day 30. Active participation of specific suppressor cells in the maintenance of unresponsiveness was suggested because data obtained in the cell transfer experiments was statistically significant. Transfer of lymphocytes from rats bearing long-term grafts showed a tendency to delay rejection of skin grafts by sublethally irradiated hosts, but it failed to delay the rapid rejection by normal lymphocytes cotransferred to the same recipients.
K Sakamoto; T Ochiai; N Shinohara; H Sato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation     Volume:  37     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-02-28     Completed Date:  1984-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-100     Citation Subset:  IM    
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MeSH Terms
Cyclosporins / therapeutic use*
Graft Survival
Heart Transplantation*
Immune Tolerance*
Lymphocytes / immunology
Rats, Inbred BN
Rats, Inbred F344
Skin Transplantation
T-Lymphocytes, Regulatory / immunology
Time Factors
Transplantation Immunology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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