Document Detail

Enflurane in patients with coronary artery disease.
MedLine Citation:
PMID:  316959     Owner:  NLM     Status:  MEDLINE    
In 12 patients with coronary artery disease, hypertensive periods during aortocoronary bypass surgery were treated with 1 MAC enflurane. The effect of enflurane on the major determinants of myocardial oxygen consumption was studied. Systolic arterial pressure was reduced to a level of about 120 mmHg (16 kPa). The heart rate diminished by 16.5%. The cardiac index during enflurane application was unchanged. Pulmonary artery wedge pressure was measured at short intervals and remained unchanged. The fall in arterial pressure and heart rate under unchanged preload produced a significant reduction in myocardial oxygen consumption as determined by calculation of the systolic wall tension and the tension time index. In five patients, the O2 content in coronary sinus blood was measured and the arterial-coronary sinus O2 difference was found to be diminished. In the concentration used, enflurane reduced the myocardial oxygen consumption of patients with coronary artery disease.
K van Ackern; N Franke; K Peter; P Schmucker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica. Supplementum     Volume:  71     ISSN:  0515-2720     ISO Abbreviation:  Acta Anaesthesiol Scand Suppl     Publication Date:  1979  
Date Detail:
Created Date:  1980-04-17     Completed Date:  1980-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370271     Medline TA:  Acta Anaesthesiol Scand Suppl     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  71-6     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Inhalation
Blood Pressure / drug effects
Coronary Artery Bypass
Coronary Disease / physiopathology*,  surgery
Enflurane / adverse effects,  pharmacology*
Heart Rate / drug effects
Hypertension / chemically induced
Middle Aged
Myocardium / metabolism
Oxygen Consumption / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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