Document Detail

Enflurane causes a prolonged and reversible increase in the rate of CSF production in the dog.
MedLine Citation:
PMID:  7125260     Owner:  NLM     Status:  MEDLINE    
Using the open ventriculocisternal perfusion method, rates of cerebrospinal fluid (CSF) production and reabsorption by bulk flow were examined in dogs anesthetized with either enflurane (2.2%) in nitrogen (60-70%) and oxygen, or nitrous oxide (60-70%) and enflurane (less than 0.2%) in oxygen (controls). The mean rate of CSF production increased significantly with enflurane (2.2%), from 0.055 +/- 0.020 ml/min (mean +/- SD) in controls to 0.082 +/- 0.033 ml/min (n = 12). After this initial increase of approximately 50%, the production rate decreased significantly by about 7.4%/h. When the expired concentration of enflurane was decreased from 2.2% to less than 0.2%, the mean rate of CSF production decreased to control values at 45-50 min. An intracerebral accumulation of CSF resulting from this enflurane-induced increase in CSF production may contribute in part to increased intracranial pressure when the dura is intact.
A A Artru; M Nugent; J D Michenfelder
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  57     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  AIM; IM    
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MeSH Terms
Cerebrospinal Fluid / drug effects*,  physiology
Enflurane / pharmacology*
Nitrous Oxide / pharmacology
Time Factors
Grant Support
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 13838-16-9/Enflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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