| Enflurane causes a prolonged and reversible increase in the rate of CSF production in the dog. | |
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MedLine Citation:
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PMID: 7125260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the open ventriculocisternal perfusion method, rates of cerebrospinal fluid (CSF) production and reabsorption by bulk flow were examined in dogs anesthetized with either enflurane (2.2%) in nitrogen (60-70%) and oxygen, or nitrous oxide (60-70%) and enflurane (less than 0.2%) in oxygen (controls). The mean rate of CSF production increased significantly with enflurane (2.2%), from 0.055 +/- 0.020 ml/min (mean +/- SD) in controls to 0.082 +/- 0.033 ml/min (n = 12). After this initial increase of approximately 50%, the production rate decreased significantly by about 7.4%/h. When the expired concentration of enflurane was decreased from 2.2% to less than 0.2%, the mean rate of CSF production decreased to control values at 45-50 min. An intracerebral accumulation of CSF resulting from this enflurane-induced increase in CSF production may contribute in part to increased intracranial pressure when the dura is intact. |
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Authors:
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A A Artru; M Nugent; J D Michenfelder |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Anesthesiology Volume: 57 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 255-60 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebrospinal Fluid / drug effects*, physiology Dogs Enflurane / pharmacology* Nitrous Oxide / pharmacology Pressure Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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NS-7507/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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10024-97-2/Nitrous Oxide; 13838-16-9/Enflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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