| Energy restriction restores the impaired immune response in overweight (cafeteria) rats. | |
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MedLine Citation:
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PMID: 15219927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired immune function linked to obesity has been shown in both human and animal studies. The purpose of this work was to evaluate the effects of a 4-week energy restriction (50% of total energy intake) on immune function in previously diet-induced (cafeteria) overweight rats. Flow cytometric analysis revealed that the number of spleen T helper cells were significantly (P < 0.05) elevated in control and overweight energy-restricted rats as compared with groups fed ad libitum groups. The proliferative response of splenocytes to phytohaemaglutinin and concanavalin A from overweight rats after energy restriction was significantly (P < 0.05) higher compared to overweight nonrestricted rats. The cytotoxic activity of natural killer cells tended to be lower in overweight rats compared to controls. Finally, control rats under the dietary deprivation period presented higher levels of uncoupling protein 2 mRNA and lower levels of leptin receptor mRNA compared with the reference control group. These results suggest that energy restriction is able to restore, at least in part, the impaired immune response commonly observed in overweight animals. |
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Authors:
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Oscar Lamas; J Alfredo Martínez; Amelia Marti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 15 ISSN: 0955-2863 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-28 Completed Date: 2004-12-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 418-25 Citation Subset: IM |
Affiliation:
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Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Body Weight Cell Division / drug effects Concanavalin A / pharmacology Cytotoxicity, Immunologic Diet, Reducing* Energy Intake* Flow Cytometry Immunity* Ion Channels Killer Cells, Natural / immunology Male Membrane Transport Proteins / genetics Mitochondrial Proteins / genetics Obesity / diet therapy*, immunology* Phytohemagglutinins / pharmacology RNA, Messenger / analysis Rats Rats, Wistar Receptors, Cell Surface / genetics Receptors, Leptin Spleen / chemistry, cytology T-Lymphocytes, Helper-Inducer Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Ion Channels; 0/Membrane Transport Proteins; 0/Mitochondrial Proteins; 0/Phytohemagglutinins; 0/RNA, Messenger; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/Triglycerides; 0/mitochondrial uncoupling protein 2; 11028-71-0/Concanavalin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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