| Energy metabolism and tissue blood flow as parameters for the assessment of graft viability in rat small bowel transplantation. | |
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MedLine Citation:
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PMID: 8943104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The assessment of small bowel graft viability by means of energy metabolism and tissue blood flow was investigated and compared with pathological findings. Syngeneic heterotopic small bowel transplantations were performed using male Lewis rats, which were divided into four groups according to the duration of cold preservation in University of Wisconsin (UW) solution; 6-, 12-, 24-, and 48-hour groups. The adenine nucleotide metabolism, the tissue blood flow, and the pathological profiles of the grafts were all compared among the groups. The adenosine triphosphate (ATP) levels at the end of cold storage and at 30 minutes after reperfusion, as well as the total adenine nucleotide (TAN) levels at the end of cold storage, before reperfusion, and at 30 minutes after reperfusion were significantly lower in the 48-hour group than those in the other groups, and the blood flow level at reperfusion was significantly lower in the 48-hour group than that in the others. Histological damage after reperfusion extended deep into the crypt layer in the 48-hour group but was confined to within villi in the other groups. These results suggest that the tissue ATP, TAN, and the blood flow levels are considered useful parameters for the assessment of small bowel graft viability. |
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Authors:
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T Yamada; T Taguchi; S Suita |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 31 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-03-20 Completed Date: 1997-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1475-81 Citation Subset: IM |
Affiliation:
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Department of Pediatric Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine Nucleotides
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metabolism Animals Energy Metabolism* Graft Survival* Intestine, Small / blood supply*, pathology, transplantation* Laser-Doppler Flowmetry Male Models, Biological Predictive Value of Tests Rats Rats, Inbred Lew Regional Blood Flow Reperfusion Injury / pathology Statistics, Nonparametric Time Factors Tissue Preservation / methods* |
| Chemical | |
Reg. No./Substance:
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0/Adenine Nucleotides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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