| Energy metabolism and selective neuronal vulnerability following global cerebral ischemia. | |
| | |
MedLine Citation:
|
PMID: 1407279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A short period of global ischemia results in the death of selected subpopulations of neurons. Some advances have been made in understanding events which might contribute to the selectivity of this damage but the cellular changes which culminate in neuronal death remain poorly defined. This overview examines the metabolic state of tissue in the post-ischemic period and the relationship of changes to the development of damage in areas containing ischemia-susceptible neurons. During early recirculation there is substantial recovery of ATP, phosphocreatine and related metabolites in all brain regions. However, this recovery does not signal restitution of normal energy metabolism as reductions of the oxidative metabolism of glucose are seen in many areas and may persist for several days. Furthermore, decreases in pyruvate-supported respiration develop in mitochondria from at least one ischemia-susceptible region at times coincident with the earliest histological evidence of ischemia-induced degeneration. These mitochondrial changes could simply be an early marker of irreversible damage but the available evidence is equally consistent with these contributing to the degenerative process and offering a potential site for therapeutic intervention. |
| | |
Authors:
|
N R Sims |
Related Documents
:
|
1414259 - Estimation of the total number of neurons in different brain areas in the mongolian ger... 15939539 - Ischemic preconditioning prevents protein aggregation after transient cerebral ischemia. 18495119 - Resveratrol attenuates early pyramidal neuron excitability impairment and death in acut... 3022889 - Increased vascularity and alterations in cytochrome oxidase distribution associated wit... 15665939 - Free radical lipid oxidation in brain cortex neurons and neuroglia during convulsions. 2309269 - Effect of hyperglycemia on neuronal changes in a rabbit model of focal cerebral ischemia. 11336909 - Disinhibition of somatosensory and motor cortex in mitochondriopathy without myoclonus. 21068269 - Organization of the macaque extrastriate visual cortex re-examined using the principle ... 16783919 - Units in the cerebral cortex of the anaesthetized rat and the correlations between thei... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Neurochemical research Volume: 17 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 1992 Sep |
Date Detail:
|
Created Date: 1992-11-02 Completed Date: 1992-11-02 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 923-31 Citation Subset: IM |
Affiliation:
|
Department of Medical Biochemistry, Flinders University of South Australia, Adelaide. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / metabolism Brain Ischemia / metabolism*, pathology Cell Death / physiology Energy Metabolism / physiology* Humans Nerve Degeneration / physiology* Neurons / pathology* Reperfusion |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel brain-specific bovine cDNA for a developmentally regulated mRNA encoding a putative new member...
Next Document: Monoclonal antibody 14E recognizes an antigen common to human oligodendrocytes, Schwann cells, Bergm...