| Energy metabolism in rats with ventromedial hypothalamic lesions. | |
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MedLine Citation:
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PMID: 6720886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats with ventromedial hypothalamic lesions (VMH) have increased ability to accumulate energy. The aim of this investigation was to characterize the main processes responsible for the reduced energy expenditure, using indirect calorimetry, nitrogen, and energy balance techniques. Metabolism was studied during different metabolic conditions created by a strict feeding regimen with concentrated feeding periods. A computerized system for indirect calorimetry enabled continuous study of individual animals for prolonged time periods. We found a mean decrease of 15.5% in total energy expenditure and decreased nitrogen retention in VMH rats. Calculation of respiratory quotient (RQ), energy expenditure, and the metabolic mixture demonstrated fluctuations in metabolism in accordance with the feeding regimen. The same percent reduction in resting postabsorptive energy expenditure was found as in total expenditure. Quantitatively, this main finding means that metabolic processes that occurred both in the resting and postabsorptive state were responsible for two-thirds of the total reduction in energy expenditure, whereas only one-third could be attributed to differences in dietary-induced thermogenesis and/or physical activity. It is concluded that VMH-animals spent as much as 10.3% of their total energy expenditure on liponeogenesis compared with 2.5% in controls. |
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Authors:
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B E Hustvedt; J Jeszka; A Christophersen; A Løvø |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 246 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-30 Completed Date: 1984-05-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E319-26 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Energy Metabolism* Female Hypothalamus, Middle / physiology* Nitrogen / metabolism Oxygen Consumption Rats |
| Chemical | |
Reg. No./Substance:
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7727-37-9/Nitrogen |
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