Document Detail


Energy metabolism of experimental wounds at various oxygen environments.
MedLine Citation:
PMID:  1138632     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Energy metabolism of healing tissue was studied in experimental wounds of rats chronically breathing 11% O2, air or 55% O2. Increasing oxygen supply elevated both PO2 and PCO2 in the wound tissue. At the early phases of healing hypoxic wounds contained less DNA than normoxic or hyperoxic tissues. In hypoxia the accumulation of wound collagen was clearly retarded. Furthermore, tissue taken from wounds healing in hypoxic environments and tested ex vivo in air showed decreased capacity for glucose utilization, lactate production and oxygen consumption. Concentrations of AMP, ADP and ATP in repair tissue increased as healing progressed. The more oxygen available the higher the amounts of ADP and ATP. The AMP content was not affected by changes in local oxygen tension. These results support the earlier concept that the supply of oxygen in healing tissue may be rate-limitimg. Reduction of available oxygen either by systemic hypoxia or by increased diffusion distance impedes healing.
Authors:
J Kivisaari; T Vihersaari; S Renvall; J Niinikoski
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  181     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-09-09     Completed Date:  1975-09-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  823-8     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / metabolism
Collagen / biosynthesis
DNA / biosynthesis
Energy Metabolism*
Fibroblasts / metabolism
Granulation Tissue / metabolism
Humans
Lactates / biosynthesis
Models, Biological
Oxygen / blood,  pharmacology
Oxygen Consumption*
Phosphates / biosynthesis
Rats
Wound Healing / drug effects
Wounds and Injuries / metabolism*
Chemical
Reg. No./Substance:
0/Lactates; 0/Phosphates; 7782-44-7/Oxygen; 9007-34-5/Collagen; 9007-49-2/DNA
Comments/Corrections

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