Document Detail


Energy intake in weight-reduced humans.
MedLine Citation:
PMID:  20595050     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Almost anyone who has ever lost weight can attest that it is harder to sustain weight loss than to lose weight. Maintenance of a 10% or greater reduced body weight is accompanied by decreases in energy expenditure to levels significantly below what is predicted solely on the basis of weight and body composition changes. This disproportionate decline in energy expenditure would not be sufficient to account for the over 80% recidivism rate to pre-weight loss levels of body fatness after otherwise successful weight reduction if there were a corresponding reduction in energy intake. In fact, reduced body weight maintenance is accompanied by increased energy intake above that required to maintain reduced weight. The failure to reduce energy intake in response to decreased energy output reflects decreased satiation and perception of how much food is eaten and multiple changes in neuronal signaling in response to food which conspire with the decline in energy output to keep body energy stores (fat) above a CNS-defined minimum (threshold). Much of this biological opposition to sustained weight loss is mediated by the adipocyte-derived hormone "leptin."
Authors:
Michael Rosenbaum; Harry R Kissileff; Laurel E S Mayer; Joy Hirsch; Rudolph L Leibel
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-06-02
Journal Detail:
Title:  Brain research     Volume:  1350     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  95-102     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, NY, USA. mr475@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Body Weight / physiology*
Eating / physiology*
Energy Metabolism / physiology
Feeding Behavior / physiology*
Humans
Obesity / physiopathology*
Weight Loss / physiology*
Grant Support
ID/Acronym/Agency:
DK26687/DK/NIDDK NIH HHS; DK30583/DK/NIDDK NIH HHS; DK37948/DK/NIDDK NIH HHS; DK64773/DK/NIDDK NIH HHS; DKP30 26687//PHS HHS; P30 DK026687-179001/DK/NIDDK NIH HHS; R01 DK064773-06/DK/NIDDK NIH HHS; R01 DK064773-08/DK/NIDDK NIH HHS; RR00102/RR/NCRR NIH HHS; RR00645/RR/NCRR NIH HHS; RR024156/RR/NCRR NIH HHS; UL1 RR024156-027762/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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