Document Detail

Energy, development and fitness in Drosophila melanogaster.
MedLine Citation:
PMID:  7972164     Owner:  NLM     Status:  MEDLINE    
Perturbation of energy metabolism via NAD supplementation modifies the expression of larval development time, a genetically based trait relevant to development and whole-organism fitness in Drosophila melanogaster. The results suggest a link between energy metabolism and gene expression. Supplemental NAD significantly decreased larval development time for isofemale strains chosen on the basis of development time differences. This effect did not represent a trade-off with larval survival, and was not related to the effects of supplemental glucose. The isofemale strains were assayed by using a method derived from Warburg's manometric procedures which measured changes in the proportions of ATP, ADP and AMP in larval homogenates. Supplemental NAD appeared to increase the proportion of ATP and the [ATP]/[ADP] ratio in vitro and during larval development. The decrease in larval development time mediated by NAD was attributed to supplemental NAD modifying the NAD pool beyond levels established during development, directly altering electron transport chain activity, ATP, ADP and AMP levels, and possibly gene expression.
M J Kohane
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  257     ISSN:  0962-8452     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-12-02     Completed Date:  1994-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Department of Biological Sciences, Stanford University, California 94305.
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MeSH Terms
Adenine Nucleotides / metabolism
Azides / pharmacology
Drosophila melanogaster / genetics,  growth & development,  metabolism*
Energy Metabolism / drug effects
Gene Expression Regulation, Developmental / drug effects
Glucose / pharmacology
Larva / drug effects,  growth & development
NAD / pharmacology
Sodium Azide
Grant Support
Reg. No./Substance:
0/Adenine Nucleotides; 0/Azides; 26628-22-8/Sodium Azide; 50-99-7/Glucose; 53-84-9/NAD

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