| Energy demand of cardioplegically perfused human hearts. | |
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MedLine Citation:
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PMID: 4066739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human adult hearts with aortic valve disease (n = 20) and hypertrophic obstructive cardiomyopathy (n = 1) were perfused intraoperatively with cold histidine buffered Bretschneider solution. During a seven minute cardioplegic perfusion the temperature level, the electrolyte level, the resistance of the left (LCA) and right coronary artery (RCA), and myocardial O2 consumption were analysed. Equilibration of K+ was terminated shortly after the start of the perfusion while Na+ equilibration lasted for about 5 minutes. Resistance of RCA did not change significantly, but that of the LCA was diminished significantly (p less than 0.025) within the perfusion period indicating a delayed washout of calcium from the extracellular space. Myocardial O2 consumption was reduced from 2.71 ml/min (1. minute) to 1.51 ml/min (4. minute) to 0.93 ml/min (7. minute) although the temperature had reached a low level after 3 minutes. The difference between 4. to 7. minutes is significant (p less than 0.001). By our results it is concluded that in adult hearts high-volume cardioplegic perfusion at a flow rate of 1 ml/min X gm at a perfusion pressure of 40 to 50 mmHg should be performed for at least 6 to 7 minutes to achieve a sufficient intra-ischemic myocardial protection. |
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Authors:
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C J Preusse; J Winter; H D Schulte; W Bircks |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of cardiovascular surgery Volume: 26 ISSN: 0021-9509 ISO Abbreviation: J Cardiovasc Surg (Torino) Publication Date: 1985 Nov-Dec |
Date Detail:
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Created Date: 1986-01-14 Completed Date: 1986-01-14 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0066127 Medline TA: J Cardiovasc Surg (Torino) Country: ITALY |
Other Details:
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Languages: eng Pagination: 558-63 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aortic Valve / metabolism, surgery Cardiomyopathy, Hypertrophic / metabolism, surgery Coronary Vessels / physiopathology Electrolytes / metabolism Energy Metabolism* Female Heart Arrest, Induced* / methods Heart Valve Diseases / metabolism, surgery Humans Male Middle Aged Myocardium / metabolism* Oxygen Consumption Partial Pressure Perfusion / methods Time Factors Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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