Document Detail

Energy demand of cardioplegically perfused human hearts.
MedLine Citation:
PMID:  4066739     Owner:  NLM     Status:  MEDLINE    
Human adult hearts with aortic valve disease (n = 20) and hypertrophic obstructive cardiomyopathy (n = 1) were perfused intraoperatively with cold histidine buffered Bretschneider solution. During a seven minute cardioplegic perfusion the temperature level, the electrolyte level, the resistance of the left (LCA) and right coronary artery (RCA), and myocardial O2 consumption were analysed. Equilibration of K+ was terminated shortly after the start of the perfusion while Na+ equilibration lasted for about 5 minutes. Resistance of RCA did not change significantly, but that of the LCA was diminished significantly (p less than 0.025) within the perfusion period indicating a delayed washout of calcium from the extracellular space. Myocardial O2 consumption was reduced from 2.71 ml/min (1. minute) to 1.51 ml/min (4. minute) to 0.93 ml/min (7. minute) although the temperature had reached a low level after 3 minutes. The difference between 4. to 7. minutes is significant (p less than 0.001). By our results it is concluded that in adult hearts high-volume cardioplegic perfusion at a flow rate of 1 ml/min X gm at a perfusion pressure of 40 to 50 mmHg should be performed for at least 6 to 7 minutes to achieve a sufficient intra-ischemic myocardial protection.
C J Preusse; J Winter; H D Schulte; W Bircks
Related Documents :
25148129 - The development of a novel measure to assess motives for compensatory eating in respons...
7795719 - Adenosine: a new agent in the diagnosis of impotence.
10577439 - Relation between aerobic capacity and extent of myocardial ischemia in patients with no...
8824479 - Hepatic nucleotide triphosphate regeneration after hypothermic reperfusion in the pig m...
111639 - Intravascular coagulation and fibrinolysis within primate extremities during tourniquet...
12679219 - Exercise-induced ischemia initiates the second window of protection in humans independe...
2729129 - Exercise stress-induced changes in systemic arterial potassium in angina pectoris.
7837949 - Indomethacin potentiates exercise-induced reduction in renal hemodynamics in athletes.
7484689 - Leg cramps: differential diagnosis and management.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of cardiovascular surgery     Volume:  26     ISSN:  0021-9509     ISO Abbreviation:  J Cardiovasc Surg (Torino)     Publication Date:    1985 Nov-Dec
Date Detail:
Created Date:  1986-01-14     Completed Date:  1986-01-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0066127     Medline TA:  J Cardiovasc Surg (Torino)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  558-63     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aortic Valve / metabolism,  surgery
Cardiomyopathy, Hypertrophic / metabolism,  surgery
Coronary Vessels / physiopathology
Electrolytes / metabolism
Energy Metabolism*
Heart Arrest, Induced* / methods
Heart Valve Diseases / metabolism,  surgery
Middle Aged
Myocardium / metabolism*
Oxygen Consumption
Partial Pressure
Perfusion / methods
Time Factors
Vascular Resistance
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nineteen year experience on the treatment of aneurysms of the abdominal aorta: a survey of 832 conse...
Next Document:  Reoperation after initial correction of tetralogy of Fallot.