Document Detail


Energy demand of cardioplegically perfused human hearts.
MedLine Citation:
PMID:  4066739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human adult hearts with aortic valve disease (n = 20) and hypertrophic obstructive cardiomyopathy (n = 1) were perfused intraoperatively with cold histidine buffered Bretschneider solution. During a seven minute cardioplegic perfusion the temperature level, the electrolyte level, the resistance of the left (LCA) and right coronary artery (RCA), and myocardial O2 consumption were analysed. Equilibration of K+ was terminated shortly after the start of the perfusion while Na+ equilibration lasted for about 5 minutes. Resistance of RCA did not change significantly, but that of the LCA was diminished significantly (p less than 0.025) within the perfusion period indicating a delayed washout of calcium from the extracellular space. Myocardial O2 consumption was reduced from 2.71 ml/min (1. minute) to 1.51 ml/min (4. minute) to 0.93 ml/min (7. minute) although the temperature had reached a low level after 3 minutes. The difference between 4. to 7. minutes is significant (p less than 0.001). By our results it is concluded that in adult hearts high-volume cardioplegic perfusion at a flow rate of 1 ml/min X gm at a perfusion pressure of 40 to 50 mmHg should be performed for at least 6 to 7 minutes to achieve a sufficient intra-ischemic myocardial protection.
Authors:
C J Preusse; J Winter; H D Schulte; W Bircks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of cardiovascular surgery     Volume:  26     ISSN:  0021-9509     ISO Abbreviation:  J Cardiovasc Surg (Torino)     Publication Date:    1985 Nov-Dec
Date Detail:
Created Date:  1986-01-14     Completed Date:  1986-01-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0066127     Medline TA:  J Cardiovasc Surg (Torino)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  558-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aortic Valve / metabolism,  surgery
Cardiomyopathy, Hypertrophic / metabolism,  surgery
Coronary Vessels / physiopathology
Electrolytes / metabolism
Energy Metabolism*
Female
Heart Arrest, Induced* / methods
Heart Valve Diseases / metabolism,  surgery
Humans
Male
Middle Aged
Myocardium / metabolism*
Oxygen Consumption
Partial Pressure
Perfusion / methods
Time Factors
Vascular Resistance
Chemical
Reg. No./Substance:
0/Electrolytes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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