Document Detail

Energy balance in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  2048807     Owner:  NLM     Status:  MEDLINE    
A substantial number of patients with chronic obstructive pulmonary disease (COPD) suffer from gradual and significant weight loss during the natural course of their illness. The aim of this study was to determine the contribution of resting energy expenditure (REE) and energy intake (E-Intake) to weight loss in 80 patients with stable COPD: age (mean +/- SEM) 65 +/- 3 yr and FEV1 1.0 +/- 0.1 L. A total of 39 patients exhibited a continued weight loss in the previous year. REE measured with a ventilated hood system was significantly (p less than 0.005) higher in weight-losing compared to weight-stable patients when values were normalized for predicted metabolic rate (117 +/- 3 and 108 +/- 2%, respectively) or kg fat-free mass using bioelectrical impedance (FFM-BI): 35.0 +/- 0.8 and 31.8 +/- 0.6 kcal/kg, respectively). Normalized values of E-Intake were not significantly different between weight-losing and weight-stable patients. REE/FFM-BI correlated significantly with FEV1 (r = 0.22, p less than 0.05), maximal inspiratory mouth pressure (Plmax; r = 0.35, p less than 0.001), and E-Intake/FFM-BI (r = 0.48, p less than 0.001). Classification in three subgroups by severity of disease, (1) FEV1 greater than 35%, (2) FEV1 less than or equal to 35%, and (3) PaO2 less than 7.3 kPa, revealed a higher prevalence of weight loss in the more compromised groups and a significantly decreased (p less than 0.05) E-Intake in the hypoxemic patients.(ABSTRACT TRUNCATED AT 250 WORDS)
A M Schols; P B Soeters; R Mostert; W H Saris; E F Wouters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  143     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-12     Completed Date:  1991-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1248-52     Citation Subset:  AIM; IM    
Department of Pulmonary Diseases, University of Limburg, Maastricht, The Netherlands.
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MeSH Terms
Body Composition
Energy Metabolism*
Lung Diseases, Obstructive / metabolism*,  pathology,  physiopathology
Respiratory Function Tests
Weight Loss

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