| Energy Substrate Partitioning and Efficiency in Individuals With Atherogenic Lipoprotein Phenotype. | |
| | |
MedLine Citation:
|
PMID: 21475144 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Individuals with an atherogenic lipoprotein phenotype (ALP) characterized by increased levels of small dense low-density lipoprotein (LDL) particles tend to have greater adiposity compared to unaffected subjects. We sought to determine whether this may be related to alterations in energy substrate partitioning or efficiency. These were assessed by indirect calorimetry in men with ALP (ALP(+), n = 7) and unaffected controls (ALP(-), n = 8) during rest (30 min) and exercise (10 min). Gross, net and delta efficiencies were calculated during graded leg-cycle ergometry at workloads of 10 and 50 W. Respiratory exchange ratios (RER) were significantly (P < 0.05) higher in ALP(+) vs. ALP(-) during rest (0.86 ± 0.01 vs. 0.83 ± 0.02) and exercise at 10 W (0.88 ± 0.02 vs. 0.84 ± 0.02) and 50 W (0.92 ± 0.01 vs. 0.87 ± 0.01, respectively) (P < 0.05). Lipid oxidation (kcal/min) was lower in ALP(+) vs. ALP(-) during rest (0.56 ± 0.02 vs. 0.71 ± 0.07) and exercise at 10 W (1.52 ± 0.25 vs. 2.00 ± 0.20) and 50 W (1.28 ± 0.10 vs. 2.32 ± 0.22, respectively) (P < 0.05). Gross and net efficiencies were significantly increased (P = 0.005) in ALP(+) vs. ALP(-) at 10 W. RER was correlated positively with plasma triglyceride during exercise and inversely with high-density lipoprotein (HDL) cholesterol and LDL peak particle diameter during rest and exercise (P < 0.05). These findings suggest that increased muscular efficiency at low exercise intensity and reduced lipid oxidation during rest and exercise may contribute to both dyslipidemia and increased adiposity in individuals with ALP. |
| | |
Authors:
|
Nastaran Faghihnia; Patty W Siri-Tarino; Ronald M Krauss; George A Brooks |
Related Documents
:
|
16388444 - Effects of training on lactate kinetics parameters and their influence on short high-in... 21357444 - Pulmonary vascular resistance as assessed by bicycle stress echocardiography in patient... 21490504 - The involvement of nitric oxide and endothelin-1 in exercise-induced bronchospasm in yo... 7836734 - Angiotensin ii formation by an alternative pathway during exercise in humans. 16388444 - Effects of training on lactate kinetics parameters and their influence on short high-in... 21629604 - Cessation of exercise in the institutionalized elderly: effects on physical function. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-07 |
Journal Detail:
|
Title: Obesity (Silver Spring, Md.) Volume: - ISSN: 1930-7381 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1] Department of Integrative Biology, University of California, Berkeley, California, USA [2] Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Infusion of Glucose and Lipids at Physiological Rates Causes Acute Endoplasmic Reticulum Stress in R...
Next Document: Reduction of 8-iso-prostaglandin F2? in the first week after Roux-en-Y gastric bypass surgery.