| Energy-restricted high-fat diets only partially improve markers of systemic and adipose tissue inflammation. | |
| | |
MedLine Citation:
|
PMID: 20847734 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
This study aimed at investigating whether the weight loss due to energy-restricted high-fat diets is accompanied with parallel improvements in metabolic markers and adipose tissue inflammation. Eight-week-old C57BL/6J mice were given free access to a low-fat (LF) or a high-fat (45% of energy from fat-HF) diet for 6 months. Restricting intake of the HF diet by 30% (HFR) during the last 2 months of the HF feeding trial decreased fasting plasma insulin, homeostasis model assessment of insulin resistance (HOMA(IR)), and plasma triglyceride levels and improved hepatic steatosis compared to ad libitum HF feeding, indicating an improved metabolic profile. Further, analysis of gonadal white adipose tissue (GWAT) gene expression by microarray and quantitative PCR analyses demonstrated that HFR downregulated expression of genes linked to cell and focal adhesion, cytokine-cytokine receptor interaction, and endoplasmic reticulum (ER)-associated degradation pathway. However, HFR had no effect on circulating plasminogen activator inhibitor-1 (PAI-1) and nonesterified fatty acid levels, which were persistently higher in both HF and HFR groups compared to the LF group. Furthermore, HFR had a negative effect on plasma total adiponectin level. Finally, while HFR decreased GWAT monocyte chemotactic protein-1 (MCP-1), interleukin-2 (IL-2), and PAI-1 levels, it did not affect several other cytokines including granulocyte-macrophage colony-stimulating factor, interferon-γ, IL-1β, IL-6, and IL-10. In summary, energy-restricted high-fat diets improve insulin sensitivity, while only partially improving markers of systemic and adipose tissue inflammation. In conclusion, our study supports the recommended low-fat intake for overall cardiovascular health. |
| | |
Authors:
|
Nishan S Kalupahana; Brynn H Voy; Arnold M Saxton; Naima Moustaid-Moussa |
Related Documents
:
|
15936064 - High fat diet increases the incidence of orofacial dyskinesia and oxidative stress in s... 9822954 - The high-fat phenotype: is leptin involved in the adaptive response to a high fat (high... 14707164 - Role of endothelin-1 in blood pressure regulation in a rat model of visceral obesity an... 18385834 - Bofutsushosan, an oriental herbal medicine, attenuates the weight gain of white adipose... 2235834 - Effect of varying calcium and phosphorus level on manganese utilization. 9587674 - High density lipoproteins and coronary heart disease. future prospects in gene therapy. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-16 |
Journal Detail:
|
Title: Obesity (Silver Spring, Md.) Volume: 19 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
|
Languages: eng Pagination: 245-54 Citation Subset: IM |
Affiliation:
|
1] Department of Animal Science, University of Tennessee, Knoxville, Tennessee, USA [2] UT Obesity Research Center, Knoxville, Tennessee, USA [3] Department of Nutrition, University of Tennessee, Knoxville, Tennessee, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Potential Role for 5-Androstene-3?,7?,17?-triol in Obesity and Metabolic Syndrome.
Next Document: Correlates of participation in a pediatric primary care-based obesity prevention intervention.