| Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease. | |
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MedLine Citation:
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PMID: 23168220 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be optimized by intermittent dietary energy restriction (ER) and exercise. Such energetic challenges engage adaptive cellular stress-response signaling pathways in neurons involving neurotrophic factors, protein chaperones, DNA-repair proteins, autophagy, and mitochondrial biogenesis. By suppressing adaptive cellular stress responses, overeating and a sedentary lifestyle may increase the risk of Alzheimer's and Parkinson's diseases, stroke, and depression. Intense concerted efforts of governments, families, schools, and physicians will be required to successfully implement brain-healthy lifestyles that incorporate ER and exercise. |
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Authors:
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Mark P Mattson |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-14 |
Journal Detail:
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Title: Cell metabolism Volume: - ISSN: 1932-7420 ISO Abbreviation: Cell Metab. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. Electronic address: mattsonm@grc.nia.nih.gov. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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