| Energy Deficit as a Possible Factor for the Induction of Caspase-Dependent Apoptosis in Left Ventricular Myocardial Cells during Genetically Determined and Secondary Arterial Hypertension. | |
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MedLine Citation:
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PMID: 23113294 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Activities of caspase-3 and caspase-8 in the left ventricular myocardium of Chinchilla rabbits with renovascular arterial hypertension and spontaneously hypertensive rats were measured after 10-day administration of a macroergic compound phosphocreatine. Treatment with phosphocreatine prevented activation of caspase-3, but had no effect on caspase-8 during secondary and genetically determined arterial hypertension. Our results indicate that the intrinsic mechanism of the induction of the caspase cascade in myocardial cells dominates over the extrinsic pathway during both types of arterial hypertension. Energy deficit is one of the inducing factors of these processes. |
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Authors:
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M M Azova; M L Blagonravov; E A Demurov; V A Frolov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 153 ISSN: 1573-8221 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng; rus Pagination: 824-6 Citation Subset: IM |
Affiliation:
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Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia. azovam@mail.ru. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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