Document Detail

Energy Deficit as a Possible Factor for the Induction of Caspase-Dependent Apoptosis in Left Ventricular Myocardial Cells during Genetically Determined and Secondary Arterial Hypertension.
MedLine Citation:
PMID:  23113294     Owner:  NLM     Status:  In-Data-Review    
Activities of caspase-3 and caspase-8 in the left ventricular myocardium of Chinchilla rabbits with renovascular arterial hypertension and spontaneously hypertensive rats were measured after 10-day administration of a macroergic compound phosphocreatine. Treatment with phosphocreatine prevented activation of caspase-3, but had no effect on caspase-8 during secondary and genetically determined arterial hypertension. Our results indicate that the intrinsic mechanism of the induction of the caspase cascade in myocardial cells dominates over the extrinsic pathway during both types of arterial hypertension. Energy deficit is one of the inducing factors of these processes.
M M Azova; M L Blagonravov; E A Demurov; V A Frolov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  153     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  824-6     Citation Subset:  IM    
Department of General Pathology and Pathophysiology, People's Friendship University of Russia, Moscow, Russia.
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