| Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits. | |
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MedLine Citation:
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PMID: 18372329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The central melanocortin system is a critical contributor to energy balance control. Melanocortin receptors (MC-Rs) are widely distributed throughout forebrain and caudal brainstem nuclei. To assess the contribution of hindbrain MC-Rs to the control of energy expenditure, the MC3/4R agonist melanotan II (MTII) was delivered to either the fourth ventricle or medullary raphe of neurologically intact rats and chronic decerebrate (CD) rats, and interscapular brown adipose tissue (IBAT) temperature (T(IBAT)), core temperature (T(C)), heart rate (HR), and spontaneous activity were recorded. Fourth ventricular MTII (0.1, 1.0 nmol) significantly increased T(IBAT), T(C), and HR in intact rats (T(C): +0.33 +/- 0.08, +0.41 +/- 0.09 C; HR: +40.84 +/- 7.29, +69.04 +/- 6.83 beats per minute) and in CDs (T(C): +1.39 +/- 0.67, +1.52 +/- 0.37 C; HR: +83.21 +/- 19.2, +107.38 +/- 17.65 beats per minute). Response magnitude was greater in CD rats than in neurologically intact rats. T(IBAT), T(C), and HR were significantly increased after 10 pmol MTII delivery to the medullary raphe of intact rats, and here too, the response magnitude was greater in decerebrate rats. The hyperthermia, IBAT thermogenesis, and tachycardia observed in CD rats after fourth ventricular and hindbrain parenchymal MTII injections support the hypothesis that hindbrain MC-R stimulation engages endemic circuits that link sympathetic outflows to thermogenic and cardiac effectors, and that forebrain processing and forebrain-caudal brainstem communication are not required for response production. |
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Authors:
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Karolina P Skibicka; Harvey J Grill |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-03-27 |
Journal Detail:
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Title: Endocrinology Volume: 149 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-30 Completed Date: 2008-09-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 3605-16 Citation Subset: AIM; IM |
Affiliation:
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Graduate Group of Psychology and Graduate Group of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA. skibicka@mail.med.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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drug effects,
metabolism Animals Body Temperature / drug effects Brain Stem / drug effects, metabolism Energy Metabolism / drug effects* Heart Rate / drug effects Male Peptides, Cyclic / pharmacology* Prosencephalon / drug effects, metabolism Rats Rats, Sprague-Dawley Receptor, Melanocortin, Type 3 / agonists, metabolism, physiology Receptor, Melanocortin, Type 4 / agonists, metabolism, physiology Receptors, Melanocortin / agonists*, metabolism, physiology Rhombencephalon / drug effects, metabolism Sympathetic Nervous System / drug effects*, physiology alpha-MSH / analogs & derivatives*, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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DK 21397/DK/NIDDK NIH HHS; T32 GM 07517/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptides, Cyclic; 0/Receptor, Melanocortin, Type 3; 0/Receptor, Melanocortin, Type 4; 0/Receptors, Melanocortin; 121062-08-6/melanotan-II; 581-05-5/alpha-MSH |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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