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Enduring medial perforant path short-term synaptic depression at high pressure.
MedLine Citation:
PMID:  21048901     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The high pressure neurological syndrome develops during deep-diving (>1.1 MPa) involving impairment of cognitive functions, alteration of synaptic transmission and increased excitability in cortico-hippocampal areas. The medial perforant path (MPP), connecting entorhinal cortex with the hippocampal formation, displays synaptic frequency-dependent-depression (FDD) under normal conditions. Synaptic FDD is essential for specific functions of various neuronal networks. We used rat cortico-hippocampal slices and computer simulations for studying the effects of pressure and its interaction with extracellular Ca(2+) ([Ca(2+)](o)) on FDD at the MPP synapses. At atmospheric pressure, high [Ca(2+)](o) (4-6 mM) saturated single MPP field EPSP (fEPSP) and increased FDD in response to short trains at 50 Hz. High pressure (HP; 10.1 MPa) depressed single fEPSPs by 50%. Increasing [Ca(2+)](o) to 4 mM at HP saturated synaptic response at a subnormal level (only 20% recovery of single fEPSPs), but generated a FDD similar to atmospheric pressure. Mathematical model analysis of the fractions of synaptic resources used by each fEPSP during trains (normalized to their maximum) and the total fraction utilized within a train indicate that HP depresses synaptic activity also by reducing synaptic resources. This data suggest that MPP synapses may be modulated, in addition to depression of single events, by reduction of synaptic resources and then may have the ability to conserve their dynamic properties under different conditions.
Authors:
Adolfo E Talpalar; Michele Giugliano; Yoram Grossman
Publication Detail:
Type:  Journal Article     Date:  2010-10-15
Journal Detail:
Title:  Frontiers in cellular neuroscience     Volume:  4     ISSN:  1662-5102     ISO Abbreviation:  Front Cell Neurosci     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-04     Completed Date:  2011-07-14     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101477935     Medline TA:  Front Cell Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  128     Citation Subset:  -    
Affiliation:
Department of Physiology and Neurobiology, Faculty of Health Sciences, and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev Beer-Sheva, Israel.
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