Document Detail


Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats.
MedLine Citation:
PMID:  23294165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Social isolation (SI) rearing, a model of early life stress, results in profound behavioral alterations, including increased anxiety-like behavior, impaired sensorimotor gating and increased self-administration of addictive substances. These changes are accompanied by alterations in mesolimbic dopamine function, such as increased dopamine and metabolite tissue content, increased dopamine responses to cues and psychostimulants, and increased dopamine neuron burst firing. Using voltammetric techniques, we examined the effects of SI rearing on dopamine transporter activity, vesicular release and dopamine D2-type autoreceptor activity in the nucleus accumbens core. Long-Evans rats were housed in group (GH; 4/cage) or SI (1/cage) conditions from weaning into early adulthood [postnatal day (PD) 28-77]. After this initial housing period, rats were assessed on the elevated plus-maze for an anxiety-like phenotype, and then slice voltammetry experiments were performed. To study the enduring effects of SI rearing on anxiety-like behavior and dopamine terminal function, another cohort of similarly reared rats was isolated for an additional 4 months (until PD 174) and then tested. Our findings demonstrate that SI rearing results in lasting increases in anxiety-like behavior, dopamine release and dopamine transporter activity, but not D2 activity. Interestingly, GH-reared rats that were isolated as adults did not develop the anxiety-like behavior or dopamine changes seen in SI-reared rats. Together, our data suggest that early life stress results in an anxiety-like phenotype, with lasting increases in dopamine terminal function.
Authors:
Jordan T Yorgason; Rodrigo A España; Joanne K Konstantopoulos; Jeffrey L Weiner; Sara R Jones
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-08
Journal Detail:
Title:  The European journal of neuroscience     Volume:  37     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-08-29     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1022-31     Citation Subset:  IM    
Copyright Information:
© 2013 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Anxiety / metabolism*
Dopamine / metabolism*
Dopamine Plasma Membrane Transport Proteins / metabolism
Exocytosis
Nucleus Accumbens / growth & development,  metabolism,  physiology*
Rats
Rats, Long-Evans
Receptors, Dopamine D2 / metabolism
Signal Transduction
Social Isolation*
Grant Support
ID/Acronym/Agency:
F31 AA020439/AA/NIAAA NIH HHS; F31 AA020439/AA/NIAAA NIH HHS; P01 AA017056/AA/NIAAA NIH HHS; P01 AA021099/AA/NIAAA NIH HHS; R01 AA017531/AA/NIAAA NIH HHS; R37 AA010422/AA/NIAAA NIH HHS; U01 AA014091/AA/NIAAA NIH HHS; U01 AA014091/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins; 0/Receptors, Dopamine D2; VTD58H1Z2X/Dopamine
Comments/Corrections

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