| Endurance training and obesity: effect on substrate metabolism and insulin sensitivity. | |
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MedLine Citation:
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PMID: 18379212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Obesity and type 2 diabetes mellitus are disease states associated with hallmark features such as insulin resistance and an impaired ability to oxidize lipids. It has recently been reported that an optimal exercise intensity for fat oxidation (FATmax) exists; we hypothesize that continuous exercise training at this specific intensity can lead to greater improvements in fat oxidation and insulin sensitivity than a eucaloric interval training program. METHODS: In a counterbalanced, crossover design, eight sedentary, obese, but otherwise healthy male participants performed two 4-wk blocks of endurance training, either at a predetermined intensity eliciting maximal fat oxidation (TPCON) or at 5-min intervals of +/- 20% FATmax (TPINT). During the week preceding the exercise training and 48 h after the final exercise bout, an OGTT, V O2max test, steady-state exercise, and measurements of body composition were undertaken. Diet was controlled the day before all trials (50% carbohydrate, 35% fat, and 15% protein; approximately 2900 kcal.d). Variables were compared using two-way repeated-measures analyses of variance. RESULTS: It was shown that fat oxidation rates were increased by 44% after TPCON (0.24 +/- 0.01 vs 0.35 +/- 0.03 g.min, P < 0.05) but not after TPINT, and the whole-body insulin sensitivity index was increased by 27% after TPCON (P < 0.05). These changes occurred despite no change in body weight, body mass index (BMI), waist to hip ratio (WHR), percent body fat (%BF), or V O2max. CONCLUSIONS: A continuous exercise training protocol that can elicit high rates of fat oxidation increases the contribution of fat to substrate oxidation during exercise and can significantly increase insulin sensitivity compared with a eucaloric interval protocol. |
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Authors:
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Michelle C Venables; Asker E Jeukendrup |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 40 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-04-01 Completed Date: 2008-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 495-502 Citation Subset: IM; S |
Affiliation:
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School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Adult Body Composition Cross-Over Studies Diabetes Mellitus, Type 2 / metabolism Diet Energy Metabolism Exercise Therapy* Great Britain Humans Insulin / metabolism* Insulin Resistance Male Middle Aged Obesity / metabolism, physiopathology* Oxygen Consumption Physical Endurance* |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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