Document Detail


Endurance training increases metabolic rate and norepinephrine appearance rate in older individuals.
MedLine Citation:
PMID:  1872385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the effects of an 8-wk endurance training program (cycling exercise) on resting metabolic rate (RMR) and norepinephrine (NE) kinetics in 19 older persons (64 +/- 1.6 yr). Before and after training, RMR, NE kinetics, maximal O2 consumption (VO2max), body composition, supine blood pressure, estimated energy intake, and fasting levels of glucose, insulin, and thyroid hormones were measured. RMR increased 10% after training. Resting concentrations of NE increased 24% after training due to a 21% increase in NE appearance rate and no change in NE clearance. Training increased VO2max (14%; P less than 0.01) and energy intake (12%; P less than 0.01), whereas no change was noted in body composition. Supine blood pressure and plasma glucose were lower after training, whereas no change was noted in fasting levels of plasma insulin. The increase in RMR was associated with a higher rate of NE appearance (r = 0.57; P = 0.05) and with increase in energy intake (r = 0.56; P = 0.05). Together these two factors accounted for 49% (r2) of the variation of the change in RMR. Changes in blood pressure were not associated with changes in NE kinetics. We conclude that endurance training increases total energy expenditure in older individuals by the direct energy cost of physical activity and by elevating RMR. This increase is partially mediated by an increased NE appearance rate and increased food intake in healthy older individuals.
Authors:
E T Poehlman; E Danforth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  261     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-19     Completed Date:  1991-09-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E233-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, College of Medicine, University of Vermont, Burlington 05405.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / metabolism*
Energy Metabolism
Female
Hormones / blood
Humans
Kinetics
Male
Metabolism*
Middle Aged
Norepinephrine / metabolism*
Physical Education and Training*
Physical Endurance*
Sex Characteristics
Statistics as Topic
Grant Support
ID/Acronym/Agency:
AG-07857/AG/NIA NIH HHS; R01 DK-39037/DK/NIDDK NIH HHS; R01-DK-18535/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Hormones; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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