Document Detail

Endurance training in MS: short-term immune responses and their relation to cardiorespiratory fitness, health-related quality of life, and fatigue.
MedLine Citation:
PMID:  24036849     Owner:  NLM     Status:  Publisher    
The influences of exercise on cytokine response, health-related quality of life (HR-QoL), and fatigue are important aspects of MS rehabilitation. Physical exercises performed within these programs are often practiced in water, but the effects of immersion have not been investigated. To investigate the influences of short-term immune responses and cardiorespiratory fitness on HR-QoL and fatigue during 3 weeks endurance training conducted on a cycle-ergometer or an aquatic-bike. Randomized controlled clinical trial in 60 MS patients. HR-QoL, fatigue, cardiorespiratory fitness, and short-term immune changes (serum concentrations in response to cardiopulmonary exercise test) of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), interleukin-6, and the soluble receptor of IL-6 (sIL-6R) were determined at the beginning and end of 3 weeks of training intervention. Subjects performed daily 30 min training at 60 % of their VO2peak. SF-36 total (p = 0.031), physical (p = 0.004), and mental health (p = 0.057) scores show time effects within both groups. Between-group effects were shown for FSMC total (p = 0.040) and motor function score (p = 0.041). MFIS physical fatigue showed time effects (p = 0.008) for both groups. Linear regression models showed relationships between short-term immune responses and cardiorespiratory fitness with HR-QoL and fatigue after the intervention. This study indicates beneficial effects of endurance training independent of the training setting. Short-term immune adaptations and cardiorespiratory fitness have the potential to influence HR-QoL and fatigue in persons with MS. The specific immune responses of immersion to exercise need further clarification.
J Bansi; W Bloch; U Gamper; S Riedel; J Kesselring
Related Documents :
7240379 - Plasma melatonin increases during exercise in women.
3840999 - Co-release of neuropeptide y and catecholamines during physical exercise in man.
21427609 - Seasonal aerobic performance variations in elite soccer players.
14767419 - Effect of sprint duration (6 s or 30 s) on plasma glucose regulation in untrained male ...
24875979 - Diet and exercise interventions following coronary artery bypass graft surgery: a revie...
6386559 - The effect of starvation on the gastro-entero-pancreatic hormonal and metabolic respons...
2711539 - Influence of vibration on work performance during ergometer cycling.
2989349 - Acute and long-term effects of enalapril on the cardiovascular response to exercise and...
8099699 - Effects of beta 2-receptor agonists on airway responsiveness.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-14
Journal Detail:
Title:  Journal of neurology     Volume:  -     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Kliniken-Valens, Department of Sports Therapy, Rehabilitationsklinik Valens, 7317, Valens, Switzerland,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria.
Next Document:  Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.