Document Detail

Endurance training changes central and peripheral responses to physostigmine.
MedLine Citation:
PMID:  1594645     Owner:  NLM     Status:  MEDLINE    
Whether the pharmacodynamics of physostigmine (Phy) [rate of decarbamylation of cholinesterase (ChE) enzyme] (Kd) is altered due to acute and/or trained exercise in brain and various tissues of rat has been addressed. Acute exercise (AE) + Phy increased, whereas endurance training (ET) + Phy decreased ChE activity in brain, red blood cells (RBC), and various tissues as compared to Phy alone. The Kd of brain ChE was significantly increased (181% of control) by AE + Phy and decreased (66% of control) by ET + Phy as compared to Phy alone. There was a slight increase (114% of control) in Kd of RBC-ChE in AE + Phy as compared to Phy alone. The Kd of heart ChE was significantly decreased (44% of control) by ET + Phy as compared to Phy alone. The Kd of diaphragm ChE was significantly increased (384% of control) in AE + Phy and decreased (80% of control) in ET + Phy as compared to Phy alone. The Kd of muscle ChE significantly decreased (67% of control) by AE + Phy as compared to Phy alone, but ET + Phy did not affect the Kd in muscle. These results suggested that AE and ET have opposite effects on Kd after Phy administration.
S M Somani; S N Dube
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  41     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-30     Completed Date:  1992-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  773-81     Citation Subset:  IM    
Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield 62794-9230.
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MeSH Terms
Brain / enzymology
Cholinesterases / analysis*
Diaphragm / enzymology
Muscles / enzymology
Myocardium / enzymology
Physical Endurance / physiology*
Physostigmine / administration & dosage,  pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
57-47-6/Physostigmine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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