| Endurance training changes central and peripheral responses to physostigmine. | |
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MedLine Citation:
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PMID: 1594645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether the pharmacodynamics of physostigmine (Phy) [rate of decarbamylation of cholinesterase (ChE) enzyme] (Kd) is altered due to acute and/or trained exercise in brain and various tissues of rat has been addressed. Acute exercise (AE) + Phy increased, whereas endurance training (ET) + Phy decreased ChE activity in brain, red blood cells (RBC), and various tissues as compared to Phy alone. The Kd of brain ChE was significantly increased (181% of control) by AE + Phy and decreased (66% of control) by ET + Phy as compared to Phy alone. There was a slight increase (114% of control) in Kd of RBC-ChE in AE + Phy as compared to Phy alone. The Kd of heart ChE was significantly decreased (44% of control) by ET + Phy as compared to Phy alone. The Kd of diaphragm ChE was significantly increased (384% of control) in AE + Phy and decreased (80% of control) in ET + Phy as compared to Phy alone. The Kd of muscle ChE significantly decreased (67% of control) by AE + Phy as compared to Phy alone, but ET + Phy did not affect the Kd in muscle. These results suggested that AE and ET have opposite effects on Kd after Phy administration. |
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Authors:
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S M Somani; S N Dube |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 41 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-06-30 Completed Date: 1992-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 773-81 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield 62794-9230. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / enzymology Cholinesterases / analysis* Diaphragm / enzymology Male Muscles / enzymology Myocardium / enzymology Physical Endurance / physiology* Physostigmine / administration & dosage, pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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57-47-6/Physostigmine; EC 3.1.1.8/Cholinesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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