Document Detail


Endurance training changes central and peripheral responses to physostigmine.
MedLine Citation:
PMID:  1594645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Whether the pharmacodynamics of physostigmine (Phy) [rate of decarbamylation of cholinesterase (ChE) enzyme] (Kd) is altered due to acute and/or trained exercise in brain and various tissues of rat has been addressed. Acute exercise (AE) + Phy increased, whereas endurance training (ET) + Phy decreased ChE activity in brain, red blood cells (RBC), and various tissues as compared to Phy alone. The Kd of brain ChE was significantly increased (181% of control) by AE + Phy and decreased (66% of control) by ET + Phy as compared to Phy alone. There was a slight increase (114% of control) in Kd of RBC-ChE in AE + Phy as compared to Phy alone. The Kd of heart ChE was significantly decreased (44% of control) by ET + Phy as compared to Phy alone. The Kd of diaphragm ChE was significantly increased (384% of control) in AE + Phy and decreased (80% of control) in ET + Phy as compared to Phy alone. The Kd of muscle ChE significantly decreased (67% of control) by AE + Phy as compared to Phy alone, but ET + Phy did not affect the Kd in muscle. These results suggested that AE and ET have opposite effects on Kd after Phy administration.
Authors:
S M Somani; S N Dube
Related Documents :
7505095 - The effect of exercise and zinc supplement on the hematological parameters in rats.
16836565 - In vitro variables of red blood cell components collected by apheresis and frozen 6 and...
7757245 - Preparative and analytical applications of immobilized haemoglobin.
12378645 - Pancreatic microcirculatory impairment in experimental acute pancreatitis in rats.
1837265 - Circulating leucocyte and lymphocyte subpopulations before and after intensive enduranc...
21281375 - Exercise and exercise intentions among obese and overweight individuals.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  41     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-30     Completed Date:  1992-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  773-81     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield 62794-9230.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Brain / enzymology
Cholinesterases / analysis*
Diaphragm / enzymology
Male
Muscles / enzymology
Myocardium / enzymology
Physical Endurance / physiology*
Physostigmine / administration & dosage,  pharmacology*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
57-47-6/Physostigmine; EC 3.1.1.8/Cholinesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of nicotine on the threshold for rewarding brain stimulation in rats.
Next Document:  Effects of an antitussive mixture and its constituents in rats discriminating methamphetamine from s...