Document Detail


Endurance training attenuates the oxidative stress due to acute exhaustive exercise in rat liver.
MedLine Citation:
PMID:  19009910     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate whether an 8-week treadmill training attenuates exercise-induced oxidative stress in rat liver. Male rats were divided into untrained and trained groups. Endurance training consisted of treadmill running at a speed of 2.1 km/h, 1.5 h/day, 5 days a week for 8 weeks. To see the effects of endurance training on acute exhaustive exercise induced oxidative stress, untrained and trained rats were further devided into two groups: animals killed at rest and those killed after acute exhaustive exercise, in which the rats run at 2.1 km/h (10% uphill) until exhaustion. Acute exhaustive exercise increased malondialdehyde level in untrained but not in trained rats. It decreased the activity of glutathione peroxidase and total (enzymatic plus non-enzymatic) superoxide scavenger activity in untrained rats and catalase activity in trained rats. However, it did not affect glutathione S-transferase, glutathione reductase, superoxide dismutase and non-enzymatic superoxide radical scavenger activities in both trained and untrained rats. On the other hand, endurance training decreased glutathione peroxidase and glutathione S-transferase activities. The results suggested that endurance training attenuated exercise-induced oxidative stress in liver, probably by preventing the decreases in glutathione peroxidase and total superoxide scavenger activities during exercise.
Authors:
S Taysi; N Oztasan; H Efe; M F Polat; K Gumustekin; E Siktar; E Canakci; F Akcay; S Dane; M Gul
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  95     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2008-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  337-47     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Clinical Biochemistry, University of Gaziantep, Faculty of Medicine, Gaziantep, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / metabolism
Glutathione Reductase / metabolism
Glutathione Transferase / metabolism
Liver / metabolism*
Male
Malondialdehyde / metabolism
Oxidative Stress / physiology*
Physical Conditioning, Animal / physiology*
Physical Endurance / physiology*
Rats
Rats, Sprague-Dawley
Running / physiology
Superoxide Dismutase / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 542-78-9/Malondialdehyde; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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