| Endurance exercise training effects on body fatness, VO2max, HDL-C subfractions, and glucose tolerance are influenced by a PLIN haplotype in older Caucasians. | |
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MedLine Citation:
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PMID: 19850727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perilipins are lipid droplet-coating proteins that regulate intracellular lipolysis in adipocytes. A haplotype of two perilipin gene (PLIN) single nucleotide polymorphisms, 13041A>G and 14995A>T, has been previously associated with obesity risk. Furthermore, the available data indicate that this association may be modified by sex. We hypothesized that this haplotype would associate with body fatness, aerobic fitness, and a number of cardiovascular (CV) risk factor phenotypes before and after a 6-mo endurance exercise training program in sedentary older Caucasians. The major haplotype group (13041A/14995A; n = 57) had significantly lower body mass index (BMI) and body fatness compared with noncarriers of the AA haplotype (n = 44) before the training intervention. Training improved body composition in both groups, but fatness remained higher in noncarriers than AA carriers after training. This fat retention in noncarriers blunted their maximal oxygen uptake (Vo(2 max)) adaptation to training. Female noncarriers had substantially higher concentrations of several conventionally and NMR-measured HDL-C subfractions than male noncarriers before and after training, but only minimal differences were found between the sexes in the AA haplotype group. Haplotype group differences in baseline and after-training responses to an oral glucose tolerance test (OGTT) also differed by sex, as noncarrier men had the highest baseline area under the insulin curve (insulin AUC), but were the only group to significantly improve insulin AUC with training. The insulin sensitivity index and plasma glucose responses to the OGTT were more favorable in AA carriers than noncarriers before and after training. Overall, our findings suggest that PLIN variation explains some of the interindividual differences in the response of obesity and CV phenotypes to exercise training. Furthermore, these data contribute to the growing understanding of PLIN as a candidate gene for human obesity and the cardiometabolic consequences of excess adiposity. |
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Authors:
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Nathan T Jenkins; Jennifer A McKenzie; Coleen M Damcott; Sarah Witkowski; James M Hagberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-10-22 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 108 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-17 Completed Date: 2010-06-04 Revised Date: 2011-10-17 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 498-506 Citation Subset: IM |
Affiliation:
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Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742-2611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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genetics Adiposity / ethnology, genetics* Age Factors Aged Biological Markers / blood Blood Glucose / metabolism* Body Mass Index Cardiovascular Diseases / blood, ethnology, genetics*, prevention & control Chi-Square Distribution Cholesterol, HDL / blood* European Continental Ancestry Group / genetics* Female Gene Frequency Glucose Tolerance Test Haplotypes Humans Insulin / blood Male Middle Aged Obesity / complications, ethnology, genetics Oxygen Consumption / genetics* Phenotype Phosphoproteins / genetics* Physical Endurance / genetics* Polymorphism, Single Nucleotide Risk Factors Sex Factors Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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AG-00268/AG/NIA NIH HHS; AG-015389/AG/NIA NIH HHS; AG-017474/AG/NIA NIH HHS; DK-072488/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Cholesterol, HDL; 0/Phosphoproteins; 0/Triglycerides; 0/perilipin 1; 11061-68-0/Insulin |
| Comments/Corrections | |
Comment In:
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J Appl Physiol. 2010 Mar;108(3):477-8
[PMID:
20075266
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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