Document Detail


Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans.
MedLine Citation:
PMID:  10751189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of a 38-day endurance exercise training program on leucine turnover and substrate metabolism during a 90-min exercise bout at 60% peak O(2) consumption (VO(2 peak)) in 6 males and 6 females. Subjects were studied at both the same absolute (ABS) and relative (REL) exercise intensities posttraining. Training resulted in a significant increase in whole body VO(2 peak) and skeletal muscle citrate synthase (CS; P < 0.001), complex I-III (P < 0.05), and total branched-chain 2-oxoacid dehydrogenase (BCOAD; P < 0.001) activities. Leucine oxidation increased during exercise for the pretraining trial (PRE, P < 0.001); however, there was no increase for either the ABS or REL posttraining trial. Leucine oxidation was significantly lower for females at all time points during rest and exercise (P < 0.01). The percentage of BCOAD in the activated state was significantly increased after exercise for both the PRE and REL exercise trials, with the increase in PRE being greater (P < 0.001) compared with REL (P < 0.05). Females oxidized proportionately more lipid and less carbohydrate during exercise compared with males. In conclusion, we found that 38 days of endurance exercise training significantly attenuated both leucine oxidation and BCOAD activation during 90 min of endurance exercise at 60% VO(2 peak) for both ABS and REL exercise intensities. Furthermore, females oxidize proportionately more lipid and less carbohydrate compared with males during endurance exercise.
Authors:
S McKenzie; S M Phillips; S L Carter; S Lowther; M J Gibala; M A Tarnopolsky
Related Documents :
10936129 - Exercise capacity of thoracotomy patients in the early postoperative period.
22976739 - Effects of 12 weeks of aerobic exercise on body composition and vascular compliance in ...
12032409 - Kinetics of co(2) excessive expiration in constant-load exercise.
16037619 - Effect of chronic use of different propulsion systems in wheelchair design on the aerob...
19793579 - Cardiorespiratory responses of firefighters to a computerized fire strategies and tacti...
23046739 - Exercise training performed simultaneously to a high-fat diet reduces the degree of ins...
19771449 - Exponential protocols for cardiopulmonary exercise testing on treadmill and cycle ergom...
17615999 - Alterations of autonomic nervous activity and energy metabolism by capsaicin ingestion ...
10527309 - The effect of prolonged exercise on lipid peroxidation in eumenorrheic female runners.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  278     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-01     Completed Date:  2000-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E580-7     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Adaptation, Physiological
Adult
Blood Glucose / metabolism
Body Composition / physiology
Citrate (si)-Synthase / metabolism
Female
Glycogen / metabolism
Humans
Ketone Oxidoreductases / metabolism*
Leucine / metabolism*
Male
Mitochondria, Muscle / metabolism
Multienzyme Complexes / metabolism*
Oxidation-Reduction
Oxygen Consumption / physiology
Physical Endurance / physiology*
Physical Fitness / physiology*
Proteins / metabolism
Sex Characteristics
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Multienzyme Complexes; 0/Proteins; 61-90-5/Leucine; 9005-79-2/Glycogen; EC 1.2.-/Ketone Oxidoreductases; EC 1.2.4.4/3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); EC 2.3.3.1/Citrate (si)-Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle.
Next Document:  Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after ...