Document Detail

Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans.
MedLine Citation:
PMID:  10751189     Owner:  NLM     Status:  MEDLINE    
We studied the effects of a 38-day endurance exercise training program on leucine turnover and substrate metabolism during a 90-min exercise bout at 60% peak O(2) consumption (VO(2 peak)) in 6 males and 6 females. Subjects were studied at both the same absolute (ABS) and relative (REL) exercise intensities posttraining. Training resulted in a significant increase in whole body VO(2 peak) and skeletal muscle citrate synthase (CS; P < 0.001), complex I-III (P < 0.05), and total branched-chain 2-oxoacid dehydrogenase (BCOAD; P < 0.001) activities. Leucine oxidation increased during exercise for the pretraining trial (PRE, P < 0.001); however, there was no increase for either the ABS or REL posttraining trial. Leucine oxidation was significantly lower for females at all time points during rest and exercise (P < 0.01). The percentage of BCOAD in the activated state was significantly increased after exercise for both the PRE and REL exercise trials, with the increase in PRE being greater (P < 0.001) compared with REL (P < 0.05). Females oxidized proportionately more lipid and less carbohydrate during exercise compared with males. In conclusion, we found that 38 days of endurance exercise training significantly attenuated both leucine oxidation and BCOAD activation during 90 min of endurance exercise at 60% VO(2 peak) for both ABS and REL exercise intensities. Furthermore, females oxidize proportionately more lipid and less carbohydrate compared with males during endurance exercise.
S McKenzie; S M Phillips; S L Carter; S Lowther; M J Gibala; M A Tarnopolsky
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  278     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-01     Completed Date:  2000-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E580-7     Citation Subset:  IM    
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Adaptation, Physiological
Blood Glucose / metabolism
Body Composition / physiology
Citrate (si)-Synthase / metabolism
Glycogen / metabolism
Ketone Oxidoreductases / metabolism*
Leucine / metabolism*
Mitochondria, Muscle / metabolism
Multienzyme Complexes / metabolism*
Oxygen Consumption / physiology
Physical Endurance / physiology*
Physical Fitness / physiology*
Proteins / metabolism
Sex Characteristics
Reg. No./Substance:
0/Blood Glucose; 0/Multienzyme Complexes; 0/Proteins; 61-90-5/Leucine; 9005-79-2/Glycogen; EC 1.2.-/Ketone Oxidoreductases; EC Dehydrogenase (Lipoamide); EC (si)-Synthase

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