| Endurance exercise, plasma oxidation and cardiovascular risk. | |
| | |
MedLine Citation:
|
PMID: 15636448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Although physical activity is beneficial to health, people who exercise at high intensities throughout their lifetime may have increased cardiovascular risk. Aerobic exercise increases oxidative stress and may contribute to atherogenesis by augmented oxidation of plasma lipoproteins. The aim of this study was to examine the relationship between aerobic power and markers of oxidative stress, including the susceptibility of plasma to oxidation. METHODS AND RESULTS: Aerobic power was measured in 24 healthy men aged 29+/-9 years (mean+/-SD). Plasma was analysed from subjects of high aerobic power (HAP; VO2max, 64.6+/-6.1 ml/kg/min) and lower aerobic power (LAP;VO2max, 45.1+/-6.3 ml/kg/min) for total antioxidant capacity (TAC), malondialdehyde (MDA) and susceptibility to oxidation. Three measures were used to quantify plasma oxidizability: (1) lag time to conjugated diene formation (lag time); (2) change in absorbance at 234 nm and; (3) slope of the oxidation curve during propagation (slope). The HAP subjects had significantly lower TAC (1.38+/-0.04 versus 1.42+/-0.06 TEAC units; P < 0.05), significantly higher change in absorbance (1.55+/-0.21 versus 1.36+/-0.17 arbitrary units; P < 0.05), but no difference in MDA (P = 0.6), compared to LAP subjects. There was a significant inverse association between TAC and slope (r = -0.49; P < 0.05). Lipoprotein profiles and daily intake of nutrients did not differ between the groups. CONCLUSIONS: These findings suggest that people with high aerobic power, due to extreme endurance exercise, have plasma with decreased antioxidant capacity and higher susceptibility to oxidation, which may increase their cardiovascular risk. |
| | |
Authors:
|
James E Sharman; Dominic P Geraghty; Cecilia M Shing; David I Fraser; Jeff S Coombes |
Related Documents
:
|
2768768 - Cardiovascular and behavioral effects of aerobic exercise training in healthy older men... 20464738 - Aerobic exercise training programmes for improving physical and psychosocial health in ... 19821388 - Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patient... 16686578 - Preferred method of selecting exercise intensity in adult women. 9373378 - Sources of social support as predictors of exercise adherence in women and men ages 50 ... 16293368 - Activation of a1 and a2 noradrenergic neurons in response to running in the rat. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta cardiologica Volume: 59 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2004 Dec |
Date Detail:
|
Created Date: 2005-01-07 Completed Date: 2005-05-05 Revised Date: 2009-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
|
Languages: eng Pagination: 636-42 Citation Subset: IM |
Affiliation:
|
The University of Tasmania, Centre for Human Movement, Launceston, Australia. jsharman@soms.uq.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Cardiovascular Diseases / blood, epidemiology, metabolism Exercise Tolerance / physiology* Humans Male Middle Aged Oxidative Stress* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Aortic elasticity in patients with ankylosing spondylitis.
Next Document: Comparison of the effects of trimetazidine and diltiazem on exercise performance in patients with co...