Document Detail

Endurance exercise causes mitochondrial and oxidative stress in rat liver: effects of a combination of mitochondrial targeting nutrients.
MedLine Citation:
PMID:  19913560     Owner:  NLM     Status:  MEDLINE    
AIMS: Endurance exercise causes fatigue due to mitochondrial dysfunction and oxidative stress. In order to find an effective strategy to prevent fatigue or enhance recovery, the effects of a combination of mitochondrial targeting nutrients on physical activity, mitochondrial function and oxidative stress in exercised rats were studied.
MAIN METHODS: Rats were subjected to a four-week endurance exercise regimen following four weeks of training. The effects of exercise and nutrient treatment in rat liver were investigated by assaying oxidative stress biomarkers and activities of mitochondrial complexes.
KEY FINDINGS: Endurance exercise induced an increase in activities of complexes I, IV, and V and an increase in glutathione (GSH) levels in liver mitochondria; however, levels of ROS and malondialdehyde (MDA) and activities of complexes II and III remained unchanged. Exercise also induced a significant increase in MDA and activities of glutathione S-transferase and NADPH-quinone-oxidoreductase 1 (NQO-1) in the liver homogenate. Nutrient treatment caused amelioration of complex V and NQO-1 activities and enhancement of activities of complex I and IV, but had no effect on other parameters.
SIGNIFICANCE: These results show that endurance exercise can cause oxidative and mitochondrial stress in liver and that nutrient treatment can either ameliorate or enhance this effect, suggesting that endurance exercise-induced oxidative and mitochondrial stress may be either damaging by causing injury or beneficial by activating defense systems.
Lijuan Sun; Weili Shen; Zhongbo Liu; Shangyi Guan; Jiankang Liu; Shuzhe Ding
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-12
Journal Detail:
Title:  Life sciences     Volume:  86     ISSN:  1879-0631     ISO Abbreviation:  Life Sci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-02-19     Revised Date:  2012-05-28    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
College of Physical Education and Health, East China Normal University, Shanghai, China.
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MeSH Terms
Electron Transport Chain Complex Proteins / metabolism
Glutathione / metabolism
Glutathione Peroxidase / metabolism
Glutathione Transferase / metabolism
Liver / enzymology,  metabolism
Malondialdehyde / metabolism
Mitochondria, Liver / enzymology,  metabolism*
NAD(P)H Dehydrogenase (Quinone) / metabolism
Oxidative Stress*
Physical Endurance*
Rats, Wistar
Reactive Oxygen Species / metabolism
Reg. No./Substance:
0/Electron Transport Chain Complex Proteins; 0/Reactive Oxygen Species; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; EC Peroxidase; EC Dehydrogenase (Quinone); EC protein, rat; EC Transferase

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